|1. TYPE OF DRUG- Tobramycin|
|Tobramycin is an aminoglycoside antibiotic.
|2. INDICATIONS (USE)- Tobramycin|
|For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
|3. MECHANISM OF ACTION (MOA)- Tobramycin|
|Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
|4. ROUTES OF ADMINISTRATION- Tobramycin|
|5. ONSET OF EFFECT OR ACTION- Tobramycin|
|6. DOSAGE (DOSING INFORMATION)- Tobramycin|
|Adults:serious infection :3mg/kg/day-3 divided doses.Max : 5mg/kg/day.Children :6-7.5mg/kg/day -3-4div. doses, or 2-2.5mg/kg every 8 hourly.
|7. HALF LIFE (DURATION OF ACTION)- Tobramycin|
|The elimination half-life of tobramycin from serum is approximately 2 hours after intravenous (IV) administration.
|8. ADVERSE EFFECTS OR SIDE EFFECTS – Tobramycin|
|An allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
Ringing in the ears or changes in hearing
New or worsening respiratory problems or difficulty breathing
Muscle weakness or
|9. CONTRAINDICATIONS – Tobramycin|
|Hypersensitivity to aminoglycosides; pregnancy
|10. DRUG INTERACTIONS – Tobramycin|
|Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclosporin, amphotericin B. Decrease serum tobramycin levels with miconazole.
Potentially Fatal: Increased neuromuscular-blocking activity with magnesium and other neuromuscular-blocking agents.
|11. EXCRETION- Tobramycin|