Tobramycin

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Tobramycin

Tobramycin 2

1.       TYPE OF DRUG- Tobramycin
Tobramycin is an aminoglycoside antibiotic.

 

2.       INDICATIONS (USE)- Tobramycin
For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.

 

3.       MECHANISM OF ACTION (MOA)- Tobramycin
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.

 

4.       ROUTES OF ADMINISTRATION- Tobramycin
Injection Route.

 

5.       ONSET OF EFFECT OR ACTION- Tobramycin
30-60 mins.
6.     DOSAGE (DOSING INFORMATION)- Tobramycin
Adults:serious infection :3mg/kg/day-3 divided doses.Max : 5mg/kg/day.Children :6-7.5mg/kg/day -3-4div. doses, or 2-2.5mg/kg every 8 hourly.

 

7.       HALF LIFE (DURATION OF ACTION)- Tobramycin
The elimination half-life of tobramycin from serum is approximately 2 hours after intravenous (IV) administration.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – Tobramycin
An allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)

Ringing in the ears or changes in hearing

Dizziness

New or worsening respiratory problems or difficulty breathing

Muscle weakness or

A rash.

9.       CONTRAINDICATIONS – Tobramycin
Hypersensitivity to aminoglycosides; pregnancy

 

10.   DRUG INTERACTIONS – Tobramycin
Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclosporin, amphotericin B. Decrease serum tobramycin levels with miconazole.

Potentially Fatal: Increased neuromuscular-blocking activity with magnesium and other neuromuscular-blocking agents.

 

11.     EXCRETION- Tobramycin
URINE

 

Tobramycin 1

 

 

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