Tinidazole

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TINIDAZOLE

Tinidazole 2

1.       TYPE OF DRUG – TINIDAZOLE
Tinidazole is an antibiotic that fights bacteria in the body.

 

2.       INDICATIONS (USE) – TINIDAZOLE
This medication is an anti-parasitic, prescribed for trichomoniasis, giardiasis, bacterial vaginosis, and amebiasis. It works by killing sensitive parasites and bacteria.

 

3.       MECHANISM OF ACTION (MOA) – TINIDAZOLE
Tinidazole is a prodrug and antiprotozoal agent. The nitro group of tinidazole is reduced in Trichomonas by a ferredoxin-mediated electron transport system. The free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activity. It is suggested that the toxic free radicals covalently bind to DNA, causing DNA damage and leading to cell death. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known, though it is probably similar.

 

4.       ROUTES OF ADMINISTRATION- TINIDAZOLE
It comes as a tablet.

 

5.       ONSET OF EFFECT OR ACTION- TINIDAZOLE
Within a few hr.

 

6.       DOSAGE (DOSING INFORMATION) – TINIDAZOLE
Bacterial vaginosis

Adult: 2 g as a single dose or 2 g given on 2 consecutive days.

Renal impairment: Haemodialysis: additional dose may be needed.

 

Anaerobic bacterial infections

Adult: 2 g on 1st day, followed by 1 g daily as a single dose or 500 mg bid for 5-6 days.

Renal impairment: Haemodialysis: additional dose may be needed.

 

Endometritis

Adult: 2 g on 1st day, followed by 1 g daily as a single dose or 500 mg bid for 5-6 days.

Renal impairment: Haemodialysis: additional dose may be needed.

 

Skin and soft tissue infections

Adult: 2 g on 1st day, followed by 1 g daily as a single dose or 500 mg bid for 5-6 days.

Renal impairment: Haemodialysis: additional dose may be needed.

 

Pneumonia

Adult: 2 g on 1st day, followed by 1 g daily as a single dose or 500 mg bid for 5-6 days.

Renal impairment: Haemodialysis: additional dose may be needed.

 

Lung abscess

Adult: 2 g on 1st day, followed by 1 g daily as a single dose or 500 mg bid for 5-6 days.

Renal impairment: Haemodialysis: additional dose may be needed..

 

7.       HALF LIFE (DURATION OF ACTION) – TINIDAZOLE
12- 16 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – TINIDAZOLE
  • Central Nervous System – Peripheral neuropathy (numbness, weakness, burning pain), tingling, unsteadiness, incoordination, giddiness, sleeplessness and drowsiness.
  • Gastrointestinal – Tongue discoloration, mouth ulcer and diarrhea.
  • Hypersensitivity – Hives, itching, rash, flushing, sweating, dryness of mouth, fever, burning sensation, thirst, watery mouth and shock.
  • Genitourinary – Darkened urine.
  • Heart – Palpitations.
  • Blood – Decrease in white blood cells and platelets.
  • Miscellaneous – Increased vaginal discharge, mouth infection, liver function abnormalities, joint/muscle pain, and joint inflammation.

 

9.       CONTRAINDICATIONS – TINIDAZOLE
Contraindicated in patients during first trimester of pregnancy, breastfeeding, and hypersensitivity.

 

10.   DRUG INTERACTIONS – TINIDAZOLE
Possible decrease in absorption with colestyramine. Possible increase in anticoagulant effect of warfarin. Monitor for toxicity if used with ciclosporin, tacrolimus or lithium.

 

11.     EXCRETION- TINIDAZOLE
Via urine (as unchanged drug and metabolites), via faeces (small amounts).

 

 

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By Medifit Education

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