Theophylline

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By Medifit Education

 

THEOPHYLLINE

Theophylline 1

  1.       TYPE OF DRUG – THEOPHYLLINE
Theophylline is a xanthine derivative. Theophylline is in a class of drugs called bronchodilators.

 

  2.       INDICATIONS (USE) – THEOPHYLLINE
This medication is used to treat and prevent wheezing and trouble breathing caused by ongoing lung disease (e.g., asthma, emphysema, chronic bronchitis).

 

  3.       MECHANISM OF ACTION (MOA) – THEOPHYLLINE
It directly relaxes bronchial smooth muscles and pulmonary blood vessels. It causes in intracellular cAMP through inhibition of phosphodiesterase , prostaglandin angatonism , stimulation of endogenous catecholamines and cGMP inhibition.

 

  4.       ROUTES OF ADMINISTRATION – THEOPHYLLINE
Oral & Intra venous

 

  5.       ONSET OF EFFECT OR ACTION – THEOPHYLLINE
Within 30 mins – 1 hour.

 

  6. DOSAGE (DOSING INFORMATION) – THEOPHYLLINE
5 mg/kg loading dose (patient not receiving theophylline or aminophylline). Maintenance dose: 5 mg/kg/day. Do not exceed 400 mg/day.

 

7.       HALF LIFE (DURATION OF ACTION) – THEOPHYLLINE
8 – 12 hours.

 

  8.       ADVERSE EFFECTS OR SIDE EFFECTS – THEOPHYLLINE
Stomach pain/cramping, nausea, vomiting, diarrhea, loss of appetite, headache, trouble sleeping, irritability, restlessness, nervousness, shaking, flushing, and increased urination may occur.

 

  9.       CONTRAINDICATIONS – THEOPHYLLINE
Active peptic ulcer. Hypersensitivity, seizure disorder.

 

  10.   DRUG INTERACTIONS – THEOPHYLLINE
Theophylline is very similar to aminophylline and oxtriphylline. Do not take medications containing aminophylline or oxtriphylline while using theophylline.

 

  11. EXCRETION – THEOPHYLLINE
The elimination half-life varies: 30 hours for premature neonates, 24 hours for neonates, 3.5 hours for children ages 1 to 9, 8 hours for adult non-smokers, 5 hours for adult smokers, 24 hours for those with hepatic impairment, 12 hours for those with congestive heart failure NYHA class I-II, 24 hours for those with congestive heart failure NYHA class III-IV, 12 hours for the elderly.

 

Theophylline 2

By Medifit Education

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