Tetanus Immunoglobulin

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By Medifit Education

 

TETANUS IMMUNOGLOBULIN

Tetanus Immunoglobulin 2

1.       TYPE OF DRUG – TETANUS IMMUNOGLOBULIN
Tetanus is a serious illness that causes convulsions (seizures) and severe muscle spasms that can be strong enough to cause bone fractures of the spine.

 

2.       INDICATIONS (USE)- TETANUS IMMUNOGLOBULIN
Tetanus immune globulin is used to prevent tetanus infection (also known as lockjaw).

 

3.       MECHANISM OF ACTION (MOA) – TETANUS IMMUNOGLOBULIN
Following intramuscular injection, tetanus immune globulin provides immunity to those individuals who have low or no immunity to the toxin produced by the tetanus organism, Clostridium tetani . The antibodies act to neutralize the free form of the powerful exotoxin, tetanospasmin, produced by this bacterium.

 

4.       ROUTES OF ADMINISTRATION – TETANUS IMMUNOGLOBULIN
Injection

 

5.       ONSET OF EFFECT OR ACTION – TETANUS IMMUNOGLOBULIN
6.     DOSAGE (DOSING INFORMATION)- TETANUS IMMUNOGLOBULIN
Adults Prophylactic dose

IM 250 units. Give 500 units if wounds are severe or treatment is delayed. Dosage may be increased to 1,000 to 2,000 units. For therapy of tetanus, give 500 to 3,000 or 6,000 units. Give deep IM, preferably in upper outer quadrant of gluteal muscle.

 

Children

IM Dose is calculated on basis of body weight (4 units/kg); however, it may be advisable to administer 250 units regardless of the size of the child. The same amount of toxin is produced by the bacteria in adults and children.

 

7.       HALF LIFE (DURATION OF ACTION)- TETANUS IMMUNOGLOBULIN
28 days

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – TETANUS IMMUNOGLOBULIN
Expect some pain, tenderness, and muscle stiffness at injection site, persisting for several hours. Hives, angioedema, nephrotic syndrome, and local inflammation occur occasionally. Anaphylactic reactions are very infrequent.

 

9.       CONTRAINDICATIONS – TETANUS IMMUNOGLOBULIN
Hypersensitivity to human antibody product, thimerosal, or other components; circulating anti-IgA antibodies.

 

10.   DRUG INTERACTIONS – TETANUS IMMUNOGLOBULIN
There is no significant interaction between TIG and tetanus toxoid if given at different injection sites. To avoid inactivating vaccines containing live viruses or bacteria, give live vaccines 2 to 4 wk before or 12 wk after TIG.

 

11.     EXCRETION – TETANUS IMMUNOGLOBULIN
 

Tetanus Immunoglobulin 1

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