Streptomycin

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Streptomycin

Streptomycin 1

1.       TYPE OF DRUG- Streptomycin
Streptomycin is an antibiotic (antimycobacterial) drug.

 

2.       INDICATIONS (USE)- Streptomycin
For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).

 

3.       MECHANISM OF ACTION (MOA)- Streptomycin
Aminoglycosides like Streptomycin “irreversibly” bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

 

4.       ROUTES OF ADMINISTRATION- Streptomycin
Injection Intra muscular (IM)

 

5.       ONSET OF EFFECT OR ACTION- Streptomycin
1-2 hours.

 

6.       DOSAGE (DOSING INFORMATION)- Streptomycin
Adults :0.75-1gm/day IM

Elderly : 0.5 gm/day IM

Children : 20-40mg/kg/day IM.

 

7.       HALF LIFE (DURATION OF ACTION)- Streptomycin
24 hours.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – Streptomycin
  • Black, tarry stools
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • chest pain
  • chills
  • clumsiness
  • cough
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • fever
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • painful or difficult urination
  • sensation of spinning
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unsteadiness
  • unusual bleeding or bruising
  • unusual tiredness or weakness

 

9.       CONTRAINDICATIONS – Streptomycin
Hypersensitivity to Streptomycin is a contraindication to its use. Clinically significant hypersensitivity to other aminoglycosides may contraindicate the use of Streptomycin because of the known cross-sensitivity of patients to drugs in this class.

 

10.   DRUG INTERACTIONS – Streptomycin
Aminoglycosides and cephalosporins : nephrotoxicity. Aminoglycosides and ethacrynic acid : ototoxicity. Benzylpenicillin : synergistic effect. Indomethacin and H1 blockers : streptomycin plasma levels. Acids and alkalis : incompatible.

 

11.      EXCRETION- Streptomycin
Small amounts are excreted in milk, saliva, and sweat. Streptomycin is excreted by glomerular filtration.

 

Streptomycin 2

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