|1. TYPE OF DRUG – ROTAVIRUS VACCINE|
|The rotavirus vaccine helps protect babies against diarrhea and vomiting caused by rotavirus.
|2. INDICATIONS (USE) – ROTAVIRUS VACCINE|
|Rotavirus oral vaccine live (RotaTeq) works by helping the immune system to protect against rotavirus.
|3. MECHANISM OF ACTION (MOA) – ROTAVIRUS VACCINE|
|Live, attenuated vaccine; following immunization, immunogenicity occurs by antibody response; seroconversion is defined as antirotavirus IgA antibodies >20 U/mL post-vaccination; conveys active immunity via stimulation of production of endogenously produced antibodies
|4. ROUTES OF ADMINISTRATION – ROTAVIRUS VACCINE|
|5. ONSET OF EFFECT OR ACTION – ROTAVIRUS VACCINE|
|Onset: Antirotavirus IgA antibodies noted 1-2 months in 77-87% of infants after 2 doses administered for Rotarix; antirotavirus antibodies noted after 3 doses in 93-100% of infants for RotaTeq
|6. DOSAGE (DOSING INFORMATION) – ROTAVIRUS VACCINE|
|RotaTeq: 3 Dose Regimen
Pentavalent vaccine; prevention of rotavirus gastroenteritis caused by the G1, G2, G,3 and G4 serotypes, plus attachment protein serotype P7
Total of three 2 mL doses administered orally
First dose given at 6-12 weeks of age
Subsequent doses administered at 4-10 week intervals
Third dose should not be given after 32 weeks of age
Rotarix: 2-Dose Regimen
Prevention of rotavirus gastroenteritis caused by G1 and non-G! serotypes (G3, G4, and G9)
Total of two 1 mL doses administered orally
Administer first dose to infants beginning at 6 weeks of age
Administer second dose after an interval of at least 4 weeks and prior to 24 weeks of age
|7. HALF LIFE (DURATION OF ACTION) – ROTAVIRUS VACCINE|
|Duration: Efficacy was at 70-79% against any grade of rotavirus through two seasons
|8. ADVERSE EFFECTS OR SIDE EFFECTS – ROTAVIRUS VACCINE|
|Mild fever, diarrhea, or vomiting may occur. If any of these effects persist or worsen, tell the doctor or pharmacist promptly.
Remember that your health care professional has prescribed this medication because he or she has judged that the benefit to your child is greater than the risk of side effects. Many people using this medication do not have serious side effects.
|9. CONTRAINDICATIONS – ROTAVIRUS VACCINE|
|10. DRUG INTERACTIONS – ROTAVIRUS VACCINE|
|Some products that may interact with this vaccine include: corticosteroids taken by mouth or given by injection (such as dexamethasone), drugs that weaken the immune system (such as azathioprine, cyclosporine, cancer chemotherapy), recent blood transfusion.
|11. EXCRETION – ROTAVIRUS VACCINE|
|in stool occurs after vaccination with peak excretion around day 7 after Dose 1.