Rotavirus Vaccine

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By Medifit Education

 

ROTAVIRUS VACCINE

Rotavirus Vaccine 1

1.       TYPE OF DRUG – ROTAVIRUS VACCINE
The rotavirus vaccine helps protect babies against diarrhea and vomiting caused by rotavirus.

 

2.       INDICATIONS (USE) – ROTAVIRUS VACCINE
Rotavirus oral vaccine live (RotaTeq) works by helping the immune system to protect against rotavirus.

 

3.       MECHANISM OF ACTION (MOA) – ROTAVIRUS VACCINE
Live, attenuated vaccine; following immunization, immunogenicity occurs by antibody response; seroconversion is defined as antirotavirus IgA antibodies >20 U/mL post-vaccination; conveys active immunity via stimulation of production of endogenously produced antibodies

 

4.       ROUTES OF ADMINISTRATION – ROTAVIRUS VACCINE
ORAL

 

5.       ONSET OF EFFECT OR ACTION – ROTAVIRUS VACCINE
Onset: Antirotavirus IgA antibodies noted 1-2 months in 77-87% of infants after 2 doses administered for Rotarix; antirotavirus antibodies noted after 3 doses in 93-100% of infants for RotaTeq

 

6.    DOSAGE (DOSING INFORMATION) – ROTAVIRUS VACCINE
RotaTeq: 3 Dose Regimen

Pentavalent vaccine; prevention of rotavirus gastroenteritis caused by the G1, G2, G,3 and G4 serotypes, plus attachment protein serotype P7

Total of three 2 mL doses administered orally

First dose given at 6-12 weeks of age

Subsequent doses administered at 4-10 week intervals

Third dose should not be given after 32 weeks of age

Rotarix: 2-Dose Regimen

Prevention of rotavirus gastroenteritis caused by G1 and non-G! serotypes (G3, G4, and G9)

Total of two 1 mL doses administered orally

Administer first dose to infants beginning at 6 weeks of age

Administer second dose after an interval of at least 4 weeks and prior to 24 weeks of age

 

7.       HALF LIFE (DURATION OF ACTION) – ROTAVIRUS VACCINE
Duration: Efficacy was at 70-79% against any grade of rotavirus through two seasons

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – ROTAVIRUS VACCINE
Mild fever, diarrhea, or vomiting may occur. If any of these effects persist or worsen, tell the doctor or pharmacist promptly.

Remember that your health care professional has prescribed this medication because he or she has judged that the benefit to your child is greater than the risk of side effects. Many people using this medication do not have serious side effects.

 

9.       CONTRAINDICATIONS – ROTAVIRUS VACCINE
  • Hypersensitivity
  • Immunosuppression
  • Infants with severe combined immunodeficiency disease (SCID)
  • Infants aged <6 weeks and >32 weeks
  • History of uncorrected congenital malformation of the GI tract that would predispose infant to intussusception
  • Infants with a history of intussusceptions

 

10.   DRUG INTERACTIONS – ROTAVIRUS VACCINE
Some products that may interact with this vaccine include: corticosteroids taken by mouth or given by injection (such as dexamethasone), drugs that weaken the immune system (such as azathioprine, cyclosporine, cancer chemotherapy), recent blood transfusion.

 

11.    EXCRETION – ROTAVIRUS VACCINE
in stool occurs after vaccination with peak excretion around day 7 after Dose 1.

 

Rotavirus Vaccine 2

 

By Medifit Education

www.themedifit.in