Rifampicin

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RIFAMPICIN

Rifampicin 2

1.       TYPE OF DRUG – RIFAMPICIN
Rifampicin or rifampin is a bactericidal antibiotic drug of the rifamycin group.

 

2.       INDICATIONS (USE) – RIFAMPICIN
For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

 

3.       MECHANISM OF ACTION (MOA) – RIFAMPICIN
Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

 

4.       ROUTES OF ADMINISTRATION – RIFAMPICIN
Capsule,injection, powder, lyophilized, for solution

 

5.       ONSET OF EFFECT OR ACTION – RIFAMPICIN
Over a few days.

 

6.       DOSAGE (DOSING INFORMATION) – RIFAMPICIN
Oral

Tuberculosis

Adult: 10mg/kg daily 0r 2-3 times weekly. Max; 600 mg/day.

Child: 10-20 mg/kg daily 2-3 times weekly. Max; 600 mg/day.

 

Prophylaxis against meningococcal meningitis:

Adult: 600 mg/bid for 2 days.

Child: 1-12 years: 10 mg/kg; < 12 months: 5 mg/kg, doses to be given bid for 2 days.

 

7.       HALF LIFE (DURATION OF ACTION) – RIFAMPICIN
3.35 (+/- 0.66) hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – RIFAMPICIN
GI disturbances, pseudomembranous colitis (rare), abnormalities of liver function, fatalities in those with liver disorders, influenza- like symptoms, skin reactions, eosinophilia, transient leucopenia, thrombocytopenia, purpura, shock, drowsiness, headache, ataxia, visual disturbances, menstural irregularities. Reddish coloured urine & tears. IV: thrombophloebitis; extravasation following local irritation & inflammation. Hepatitis or shock like syndrome with hepatic involvement.

 

9.       CONTRAINDICATIONS – RIFAMPICIN
Hypersensitivity, jaundice, severe hepatic disease. IM/SC admin. Porphyria. Not to be used for treatment of meningcoccal disease.

 

10.   DRUG INTERACTIONS – RIFAMPICIN
Increased metabolism of chloramphenicol, clofibrate, dapsone, digoxin, hexobarbitone, ketaconazole & quindine. Absorption may be decreased when taken with antacids, anticholingergics, opioids & ketaconazole. Increased metabolism of losartan & its active metabolite, diazepam & nitrazepam. Reduces serum levels of aprepitant, atovaquone, bisoprolol, carvedilol, metoprolol, proanolol, buspirone, bunazosin, diltiazem, nifedipine & verapamil. Increased risk of translant rejection when used with ciclosporin, Deceases effects of tolbutamide, clofibrate, coumarin anticoagulates, diazepam & oral contraceptives. May reduce efficacy or corticosteriods in Addison’s disease & induce an addisonian crisis.

 

11.  EXCRETION – RIFAMPICIN
Less than 30% of the dose is excreted in the urine as rifampin or metabolites.

 

Rifampicin 1

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