|1. TYPE OF DRUG – RIFAMPICIN|
|Rifampicin or rifampin is a bactericidal antibiotic drug of the rifamycin group.
|2. INDICATIONS (USE) – RIFAMPICIN|
|For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
|3. MECHANISM OF ACTION (MOA) – RIFAMPICIN|
|Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
|4. ROUTES OF ADMINISTRATION – RIFAMPICIN|
|Capsule,injection, powder, lyophilized, for solution
|5. ONSET OF EFFECT OR ACTION – RIFAMPICIN|
|Over a few days.
|6. DOSAGE (DOSING INFORMATION) – RIFAMPICIN|
Adult: 10mg/kg daily 0r 2-3 times weekly. Max; 600 mg/day.
Child: 10-20 mg/kg daily 2-3 times weekly. Max; 600 mg/day.
Prophylaxis against meningococcal meningitis:
Adult: 600 mg/bid for 2 days.
Child: 1-12 years: 10 mg/kg; < 12 months: 5 mg/kg, doses to be given bid for 2 days.
|7. HALF LIFE (DURATION OF ACTION) – RIFAMPICIN|
|3.35 (+/- 0.66) hours
|8. ADVERSE EFFECTS OR SIDE EFFECTS – RIFAMPICIN|
|GI disturbances, pseudomembranous colitis (rare), abnormalities of liver function, fatalities in those with liver disorders, influenza- like symptoms, skin reactions, eosinophilia, transient leucopenia, thrombocytopenia, purpura, shock, drowsiness, headache, ataxia, visual disturbances, menstural irregularities. Reddish coloured urine & tears. IV: thrombophloebitis; extravasation following local irritation & inflammation. Hepatitis or shock like syndrome with hepatic involvement.
|9. CONTRAINDICATIONS – RIFAMPICIN|
|Hypersensitivity, jaundice, severe hepatic disease. IM/SC admin. Porphyria. Not to be used for treatment of meningcoccal disease.
|10. DRUG INTERACTIONS – RIFAMPICIN|
|Increased metabolism of chloramphenicol, clofibrate, dapsone, digoxin, hexobarbitone, ketaconazole & quindine. Absorption may be decreased when taken with antacids, anticholingergics, opioids & ketaconazole. Increased metabolism of losartan & its active metabolite, diazepam & nitrazepam. Reduces serum levels of aprepitant, atovaquone, bisoprolol, carvedilol, metoprolol, proanolol, buspirone, bunazosin, diltiazem, nifedipine & verapamil. Increased risk of translant rejection when used with ciclosporin, Deceases effects of tolbutamide, clofibrate, coumarin anticoagulates, diazepam & oral contraceptives. May reduce efficacy or corticosteriods in Addison’s disease & induce an addisonian crisis.
|11. EXCRETION – RIFAMPICIN|
|Less than 30% of the dose is excreted in the urine as rifampin or metabolites.