|1. TYPE OF DRUG- PRIMAQUINE|
|Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria.
|2. INDICATIONS (USE) – PRIMAQUINE|
|For the treatment of malaria.
|3. MECHANISM OF ACTION (MOA) – PRIMAQUINE|
|Primaquine’s mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA.
|4. ROUTES OF ADMINISTRATION- PRIMAQUINE|
|5. ONSET OF EFFECT OR ACTION- PRIMAQUINE|
|Within 1-2 hrs.
|6. DOSAGE (DOSING INFORMATION) – PRIMAQUINE|
|Adult: A course of treatment with a blood schizontocide should be given first to kill any erythrocytic parasites. 15 mg daily for 14 days, increased to higher doses or longer course if resistance in P.vivax occurs.
Child: 250 mcg/kg daily for 14 days.
|7. HALF LIFE (DURATION OF ACTION) – PRIMAQUINE|
|8. ADVERSE EFFECTS OR SIDE EFFECTS – PRIMAQUINE|
|Nausea, vomiting, epigastric distress, abdominal cramps, leukopaenia, leucocytosis, agranulocytosis, methaemoglobinemia in NADH methaemoglobin reductase-deficient individuals.
|9. CONTRAINDICATIONS – PRIMAQUINE|
|Hypersensitivity. Children <1 year. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.
|10. DRUG INTERACTIONS – PRIMAQUINE|
|Primaquine may inhibit metabolism of chloroquine. Avoid ethanol.
|11. EXCRETION- PRIMAQUINE|
|Urine (as unchanged drug)