Medifit Educationsuggests that, in order to design an effective steroid cycle, one must have a sound understanding of steroid pharmacodynamics.
Anabolic steroids bind to specific receptors present especially in reproductive tissue, muscle and fat. The anabolic steroids reduce nitrogen excretion from tissue breakdown in androgen deficient men.
Anabolic steroids, as fat-soluble hormones, are membrane-permeable and influence the nucleus of cells by direct action and their pharmacodynamics are different than that of water-soluble peptide hormones that do not have the ability to penetrate fatty cell membrane and could only affect the nucleus of target cells indirectly through their interaction with the surface receptors of the cell.
Fat-soluble hormones, anabolic steroids are membrane-permeable and influence the nucleus of cells by direct action.
Anabolic steroids’ pharmacodynamic action initiates when the membrane of the target cell and binds to an androgen receptor located in the cytoplasm of that cell is penetrated by the exogenous hormone after which the compound hormone-receptor diffuses into the nucleus. With this, the compound hormone-receptor ether alters the expression of genes or leads to activation of processes to send signals to other cell parts.