Ornidazole

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ORNIDAZOLE

Ornidazole 2

1.       TYPE OF DRUG – ORNIDAZOLE
Ornidazole is a drug that cures some protozoan infections.

 

2.       INDICATIONS (USE) – ORNIDAZOLE
This medication is an antiamoebic agent, prescribed for amoebic dysentery.

 

3.       MECHANISM OF ACTION (MOA) – ORNIDAZOLE
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves

 

4.       ROUTES OF ADMINISTRATION- ORNIDAZOLE
It comes as a tablet

 

5.       ONSET OF EFFECT OR ACTION- ORNIDAZOLE
Within 2 hours

 

6.       DOSAGE (DOSING INFORMATION) – ORNIDAZOLE
Adult- The recommended dose range is 0.5gm to 1.5gm daily for 1 to 7 days.

 

7.       HALF LIFE (DURATION OF ACTION) – ORNIDAZOLE
12 to 14 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – ORNIDAZOLE
Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness & signs of sensory and mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.

 

9.       CONTRAINDICATIONS – ORNIDAZOLE
Hypersensitivity to ornidazole or to other nitroimidazole derivatives.

 

10.   DRUG INTERACTIONS – ORNIDAZOLE
Potentiates effect of couramin- type oral anticoagulants. Prolonges the muscle- relaxants effecr of vecuronium bromide.

 

11.     EXCRETION- ORNIDAZOLE
Excretion, 85% of single oral dose is eliminated with 5 days – Urine (63%) and Feces (22%)

 

Ornidazole 1

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