|1. TYPE OF DRUG – ORNIDAZOLE|
|Ornidazole is a drug that cures some protozoan infections.
|2. INDICATIONS (USE) – ORNIDAZOLE|
|This medication is an antiamoebic agent, prescribed for amoebic dysentery.
|3. MECHANISM OF ACTION (MOA) – ORNIDAZOLE|
|Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves
|4. ROUTES OF ADMINISTRATION- ORNIDAZOLE|
|It comes as a tablet
|5. ONSET OF EFFECT OR ACTION- ORNIDAZOLE|
|Within 2 hours
|6. DOSAGE (DOSING INFORMATION) – ORNIDAZOLE|
|Adult- The recommended dose range is 0.5gm to 1.5gm daily for 1 to 7 days.
|7. HALF LIFE (DURATION OF ACTION) – ORNIDAZOLE|
|12 to 14 hours
|8. ADVERSE EFFECTS OR SIDE EFFECTS – ORNIDAZOLE|
|Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness & signs of sensory and mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
|9. CONTRAINDICATIONS – ORNIDAZOLE|
|Hypersensitivity to ornidazole or to other nitroimidazole derivatives.
|10. DRUG INTERACTIONS – ORNIDAZOLE|
|Potentiates effect of couramin- type oral anticoagulants. Prolonges the muscle- relaxants effecr of vecuronium bromide.
|11. EXCRETION- ORNIDAZOLE|
|Excretion, 85% of single oral dose is eliminated with 5 days – Urine (63%) and Feces (22%)