NSAIDs (Anti inflammatories & Analgesics)

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NSAIDS (ANTI INFLAMMATORIES & ANALGESICS)

01 NSAID

 

NSAIDS (ANTI INFLAMMATORIES & ANALGESICS) – INTRODUCTION:

NSAIDs (Anti inflammatories& Analgesics)

This abbreviation stands for non-steroidal anti-inflammatory drugs, which are medications such as Ibufprofen that are used to control pain and inflammation. Most may be purchased over the counter. One of their major side effects is that they decrease the effect of the normal blood clotting factors in blood.

 

NSAIDS (ANTI INFLAMMATORIES & ANALGESICS) – INDICATION:

Pain and discomfort – for example muscle strain/sprain, headaches, migraines, and dysmenorrhea (painful cramps during menstruation).

Fever – NSAIDs are effective at reducing body temperature.

Inflammation – NSAIDs are often used for the treatment of inflammation, as may occur in rheumatoid arthritis.

Some other conditions – sometimes NSAIDs are recommended for the treatment of menorrhagia (heavy menstrual periods).

 

NSAIDS (ANTI INFLAMMATORIES & ANALGESICS) – INFORMATION

NSAIDs are non-steroidal anti-inflammatory drugs, also known as NAIDs, non-steroidal anti-inflammatory agents/analgesics (NSAIAs) or non-steroidal anti-inflammatory medicines (NSAIMs). They are medications with analgesic (pain reducing), antipyretic (fever reducing) effects. In higher doses they also have anti-inflammatory effects – they reduce inflammation (swelling). Non-steroidal distinguishes NSAIDs from other drugs which contain steroids, which are also anti-inflammatory. NSAIDs are non-narcotic (they do not induce stupor).

The most common NSAIDs are aspirin, ibuprofen and naproxen – probably because they are available over-the-counter (OTC, no prescription required).

NSAIDs can be used for a number of conditions. While some OTC medications, others can only be accessed with a prescription. Typically, NSAIDs are used to treat the following symptoms and conditions:

  • Pain and discomfort – for example muscle strain/sprain, headaches, migraines, and dysmenorrhea (painful cramps during menstruation).
  • Fever – NSAIDs are effective at reducing body temperature.
  • Inflammation – NSAIDs are often used for the treatment of inflammation, as may occur in rheumatoid arthritis.

Some other conditions – sometimes NSAIDs are recommended for the treatment of menorrhagia (heavy menstrual periods).

NSAIDs may be taken:

  • Orally (by mouth) – available in tablet, capsule or liquid form.
  • Intravenously – by injection
  • Rectally – as a suppository through the rectum
  • They are also available as eye-drops
  • Topical NSAIDs also exist, which are applied directly onto the skin in the form of creams or gels.

Medication - Over the Counter - otc

Types of NSAIDS

NSAIDs are based on their chemical structure:

  • Propionic acid derivatives – Examples include: Ibuprofen, Naproxen, Fenoprofen, Ketoprofen, Flurbiprofen, Oxaprozin
  • Acetic acid derivatives – Examples include: Indomethacin, Sulindac, Etodolac, Diclofenac (Safety alert by FDA)
  • Enolic acid (Oxicam) derivatives – Examples include: Piroxicam, Meloxicam, Tenoxicam, Droxicam, Lornoxicam, Isoxicam
  • Fenamic acid derivatives – Examples include: Mefenamic acid, Meclofenamic acid, Flufenamic acid, Tolfenamic acid
  • Selective COX-2 inhibitors (Coxibs) – Examples include: Celecoxib (FDA alert), Rofecoxib (withdrawn from market), Valdecoxib (withdrawn from market), Parecoxib (FDA withdrawn), Lumiracoxib (TGA cancelled registration), Etoricoxib (FDA withdrawn)

By Medifit Education

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