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By Medifit Education



Norfloxacin 1

1.       TYPE OF DRUG- Norfloxacin
Norfloxacin is a synthetic chemotherapeutic antibacterial agent.


2.       INDICATIONS (USE)- Norfloxacin
Uncomplicated urinary tract infections (including cystitis)

Complicated urinary tract infections (restricted use)

Uncomplicated urethral and cervical gonorrhea (however this indication is no longer considered to be effective by some experts due to bacterial resistance)

Prostatitis due to Escherichia coli.

Syphilis treatment: Norfloxacin has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis.


3.       MECHANISM OF ACTION (MOA)- Norfloxacin
The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity.


4.       ROUTES OF ADMINISTRATION- Norfloxacin


5.       ONSET OF EFFECT OR ACTION- Norfloxacin
Within 30-60 mins.


Adults: enteric fever :400mg BD-14 days.UTI-400mg BD-3-21 days.Gonorrhoea:800mg Single dose. Acute bact.gastroenteritis:400mg.BID/TID-5 days.

Prophylaxis against sepsis in netropenic patients:400mg BID/TID upto 8 weeks.

7.       HALF LIFE (DURATION OF ACTION)- Norfloxacin


·         mild nausea or diarrhea, stomach cramps, heartburn

·         rectal pain

·         headache, dizziness

·         sweating

·         back pain or.

·         vaginal itching or discharge.

9.       CONTRAINDICATIONS – Norfloxacin


10.   DRUG INTERACTIONS – Norfloxacin
Quinolones, including norfloxacin, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e.g., caffeine, clozapine, ropinirole, tacrine, theophylline, tizanidine) may result in increased substrate drug concentrations when given in usual doses. Patients taking any of these drugs concomitantly with norfloxacin should be carefully monitored.


11.      EXCRETION- Norfloxacin
Excretion  Urine (26% to 32% as unchanged drug; 5% to 8% as metabolites).



Norfloxacin 2

By Medifit Education