Montelukast

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By Medifit Education

Montelukast

 

Montelukast 1

 

1.       TYPE OF DRUG-Montelukast
Montelukast is an LTRA (leukotriene receptor antagonist)

 

2.       INDICATIONS (USE)-Montelukast
Prevention and long-term treatment of asthma. It is also used in certain patients to relieve allergy symptoms (eg, itchy, runny, or stuffy nose; sneezing) and to prevent asthma attacks caused by exercise.

 

3.       MECHANISM OF ACTION (MOA)-Montelukast
The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. The CysLT type-1 (CysLT1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro-inflammatory cells (including eosinophils and certain myeloid stem cells).

 

4.       ROUTES OF ADMINISTRATION-Montelukast
Tablets

 

5.       ONSET OF EFFECT OR ACTION-Montelukast
24 hours

 

6.     DOSAGE (DOSING INFORMATION)-Montelukast
adults and adolescents 15 years of age and older: one 10-mg tablet.

pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.

pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg oral granules.

 

7.       HALF LIFE (DURATION OF ACTION)-Montelukast
2.7 to 5.5 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS-Montelukast
  • headache;
  • stomach pain, heartburn, upset stomach, nausea, diarrhea;
  • tooth pain;
  • tired feeling;
  • fever, stuffy nose, sore throat, cough, hoarseness; or.
  • mild rash.

 

9.       CONTRAINDICATIONS-Montelukast
Feeling Restless, Depression, Abnormal Dreams, Inflammation of Blood Vessels in the Skin, Hallucination, Involuntary Quivering, Nervous, Increased Eosinophils in the Blood, Mood Changes, Anxious, Having Thoughts of Suicide

 

10.   DRUG INTERACTIONS-Montelukast
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

 

11.    EXCRETION-Montelukast
Coupled with estimates of montelukast oral bioavailability, this indicates that montelukast and its metabolites are excreted almost exclusively via the bile

 

 

Montelukast 2

By Medifit Education

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