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By Medifit Education



Minocycline 1

1.       TYPE OF DRUG- Minocycline
Minocycline (INN) is a broad-spectrum tetracycline antibiotic.


2.       INDICATIONS (USE)- Minocycline
For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.


3.       MECHANISM OF ACTION (MOA)- Minocycline
Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.


4.       ROUTES OF ADMINISTRATION- Minocycline
Oral ,Injection.


5.       ONSET OF EFFECT OR ACTION- Minocycline
Within 4-6hours.


6.       DOSAGE (DOSING INFORMATION)- Minocycline
Adults : PID : 100mg BD-14-21 days.

Gonorrhoea : 100 mg BD-5 days in : males  /10days in females.NGU : 100mg OD x 10-14 dfays.\

Chancroid : 100mg BD -10 days.

L.G.V : 100mg BD-14-21 days.

Syphilis : 100mg BD – 16 days.

Granuloma inguinale : 100mgBD till it heals.

Children : > 8 years : intial dose 4mg/kg  followed by 4mg/kg/day divided in 2 doses.

7.       HALF LIFE (DURATION OF ACTION)- Minocycline
Upto 24 hurs.


  • Dizziness, tired feeling, spinning sensation
  • Joint or muscle pain
  • Discoloration of you skin or nails
  • Mild nausea, mild diarrhea, upset stomach
  • Mild skin rash or itching
  • Swollen tongue, discoloration of your gums or
  • Vaginal itching or discharge.
9.       CONTRAINDICATIONS – Minocycline
Hypersensitivity to minocycline, other tetracyclines. Pregnancy and lactation.


10.   DRUG INTERACTIONS – Minocycline
Major : Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderate : Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Minor : Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.


11.     EXCRETION- Minocycline
Mostly Fecal, Rest Renal.


Minocycline 2

By Medifit Education