|1. TYPE OF DRUG- Minocycline|
|Minocycline (INN) is a broad-spectrum tetracycline antibiotic.
|2. INDICATIONS (USE)- Minocycline|
|For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
|3. MECHANISM OF ACTION (MOA)- Minocycline|
|Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
|4. ROUTES OF ADMINISTRATION- Minocycline|
|5. ONSET OF EFFECT OR ACTION- Minocycline|
|6. DOSAGE (DOSING INFORMATION)- Minocycline|
|Adults : PID : 100mg BD-14-21 days.
Gonorrhoea : 100 mg BD-5 days in : males /10days in females.NGU : 100mg OD x 10-14 dfays.\
Chancroid : 100mg BD -10 days.
L.G.V : 100mg BD-14-21 days.
Syphilis : 100mg BD – 16 days.
Granuloma inguinale : 100mgBD till it heals.
Children : > 8 years : intial dose 4mg/kg followed by 4mg/kg/day divided in 2 doses.
|7. HALF LIFE (DURATION OF ACTION)- Minocycline|
|Upto 24 hurs.
|8. ADVERSE EFFECTS OR SIDE EFFECTS – Minocycline|
|9. CONTRAINDICATIONS – Minocycline|
|Hypersensitivity to minocycline, other tetracyclines. Pregnancy and lactation.
|10. DRUG INTERACTIONS – Minocycline|
|Major : Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate : Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor : Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
|11. EXCRETION- Minocycline|
|Mostly Fecal, Rest Renal.