MICONAZOLE

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By Medifit Education

 

 

MICONAZOLE

Miconazole 1

1.       TYPE OF DRUG – MICONAZOLE
Miconazole is an antifungal medication that fights infections caused by fungus.

 

2.       INDICATIONS (USE) – MICONAZOLE
Micanazole is used as a topical agent for tinea,pityriasis versicolor, otomycosis, cutaneous and vulvovaginal candidiasis.It is also used for onychomycosis.

 

3.       MECHANISM OF ACTION (MOA) – MICONAZOLE
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

 

4.       ROUTES OF ADMINISTRATION- MICONAZOLE
2 % gel, 2 % powder for topical use.

 

5.       ONSET OF EFFECT OR ACTION- MICONAZOLE
Not applicable.
6.      DOSAGE (DOSING INFORMATION) – MICONAZOLE
Vaginal candidiasis

Adult: 100 mg (as pessary or 5 g of 2% cream) inserted at night for 7-14 days. Alternatively, 100 mg bid for 7 days; 200 or 400 mg (as pessaries) daily for 3 days or 1200 mg (as pessary) as a single dose.

 

Topical/Cutaneous

Skin fungal infections

Adult: Apply 2% cream once daily.

Child: Apply 2% cream once daily.

 

7.       HALF LIFE (DURATION OF ACTION) – MICONAZOLE
24.1 hr.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – MICONAZOLE
  • Irritation
  • Burning
  • Maceration
  • Allergic contact dermatitis
  • Irritation, burning, maceration, allergic contact dermatitis (all rare)

 

9.       CONTRAINDICATIONS – MICONAZOLE
Miconazole is contraindicated in hypersensitivity, pregnancy and lactation.

 

10.   DRUG INTERACTIONS – MICONAZOLE
Avoid chewing gum while using this medication.

 

There may be other drugs that can interact with miconazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

 

11.    EXCRETION- MICONAZOLE
10-20% of an oral dose will be excreted in urine (as metabolites), 50% of an oral dose is excreted as unchanged drug in the faeces. Elimination half-life: 40 minutes (initial), 126 minutes (secondary), 24 hours (terminal).

 

 

Miconazole 3

By Medifit Education

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