Mefenamic Acid

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MEFENAMIC ACID

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1.       TYPE OF DRUG- MEFENAMIC ACID
Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs

 

2.       INDICATIONS (USE)- MEFENAMIC ACID
There is evidence that supports the use of mefenamic acid for perimenstrual migraine headache prophylaxis, with treatment starting 2 days prior to the onset of flow or 1 day prior to the expected onset of the headache and continuing for the duration of menstruation. A study also showed mefenamic acid to be a well tolerated analgesic for post-surgical pain in dental operations. For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever. Mefenamic acid is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.

 

3.       MECHANISM OF ACTION (MOA) )- MEFENAMIC ACID
Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.

 

4.       ROUTES OF ADMINISTRATION)- MEFENAMIC ACID
Oral.

 

5.       ONSET OF EFFECT OR ACTION)- MEFENAMIC ACID
1-2 hours

 

6.      DOSAGE (DOSING INFORMATION) )- MEFENAMIC ACID
Adults-250-500mg,children-over 6 months:25mg in divided doses

 

7.       HALF LIFE (DURATION OF ACTION) )- MEFENAMIC ACID
Upto 6 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS )- MEFENAMIC ACID
Upset stomach, nausea, heartburn, dizziness, drowsiness, diarrhea, and headache may occur. upset stomach, mild heartburn or stomach pain, diarrhea, constipation, bloating, gas;dizziness, headache, nervousness,skin itching or rash,dry mouth,increased sweating, runny nose,blurred vision, or ringing in your ears.

 

9.       CONTRAINDICATIONS )- MEFENAMIC ACID
Hypersencitivity,epilepsy,glaucoma,GI bleeding,inflammatory bowel disease

 

10.   DRUG INTERACTIONS )- MEFENAMIC ACID
Drug interactions may change how your medications work or increase your risk for serious side effects. Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (e.g., prednisone), fluconazole, ketorolac, lithium, methotrexate, “water pills” (diuretics such as furosemide).

 

11.     EXCRETION)- MEFENAMIC ACID
Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretions are significant pathways of elimination.

 

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By Medifit Education

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