Mebeverine

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By Medifit Education

 

MEBEVERINE

Mebeverine 3

1.       TYPE OF DRUG – MEBEVERINE
Mebeverine (HCl) is antispasmodic agent with direct action on the smooth muscle of the gastrointestinal tract. It relieves the abdominal pain and cramps

 

2.       INDICATIONS (USE) – MEBEVERINE
Irritable bowel syndrome in its primary form

Irritable bowel syndrome associated with organic lesions of the gastrointestinal tract such as; diverticulosis and diverticulitis, regional enteritis, disease of the gall bladder and gall ducts, gastric and duodenal ulcers, dysentery, and aspecific or specific inflammation of the digestive tract.

Mebeverine should be taken 20 minutes before meals.

 

3.       MECHANISM OF ACTION (MOA) – MEBEVERINE
Mebeverine is an antimuscarinic. It is also an inhibitor of calcium-depot replenishment. Musculotropic compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut, without affecting its normal motility. Mebeverine is used to relieve symptoms of irritable bowel syndrome and related intestinal disorders that are the result of spasms in the intestinal muscles. These include colicky abdominal pain and cramps, diarrhoea alternating with constipation and flatulence

 

4.       ROUTES OF ADMINISTRATION- MEBEVERINE
administered orally

 

5.       ONSET OF EFFECT OR ACTION – MEBEVERINE
Repidly absorbed form the GI tract ( oral) ; peak plasma concentrations within 1-3 hour.

 

6.  DOSAGE (DOSING INFORMATION) – MEBEVERINE
135 mg 3 times daily, preferably 20 minutes before meals. When the desired effect has been obtained the dosage may be reduced gradually. At least for 6 weeks.

 

7.       HALF LIFE (DURATION OF ACTION) – MEBEVERINE
about 2 hours.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – MEBEVERINE
Side effects may include :

  • Indigestion or heartburn
  • Constipation
  • Dizziness
  • Insomnia (difficulty sleeping)
  • anorexia (loss of appetite)
  • Headache
  • Tiredness
  • Slow heart beat
  • Rash and/or itchy skin
  • Nausea

 

9.       CONTRAINDICATIONS – MEBEVERINE
Neonates and children under 2 years , lactation.
10.   DRUG INTERACTIONS – MEBEVERINE
Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of: none known

This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.

 

11.  EXCRETION – MEBEVERINE
The  urinary excretion of mebeveinr acid within the first 4 h after dosing amounted to 67% of the mebeverine dose.(median range : 23 – 107 %)

 

Mebeverine 1

By Medifit Education

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