|1. TYPE OF DRUG – MEBEVERINE|
|Mebeverine (HCl) is antispasmodic agent with direct action on the smooth muscle of the gastrointestinal tract. It relieves the abdominal pain and cramps
|2. INDICATIONS (USE) – MEBEVERINE|
|Irritable bowel syndrome in its primary form
Irritable bowel syndrome associated with organic lesions of the gastrointestinal tract such as; diverticulosis and diverticulitis, regional enteritis, disease of the gall bladder and gall ducts, gastric and duodenal ulcers, dysentery, and aspecific or specific inflammation of the digestive tract.
Mebeverine should be taken 20 minutes before meals.
|3. MECHANISM OF ACTION (MOA) – MEBEVERINE|
|Mebeverine is an antimuscarinic. It is also an inhibitor of calcium-depot replenishment. Musculotropic compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut, without affecting its normal motility. Mebeverine is used to relieve symptoms of irritable bowel syndrome and related intestinal disorders that are the result of spasms in the intestinal muscles. These include colicky abdominal pain and cramps, diarrhoea alternating with constipation and flatulence
|4. ROUTES OF ADMINISTRATION- MEBEVERINE|
|5. ONSET OF EFFECT OR ACTION – MEBEVERINE|
|Repidly absorbed form the GI tract ( oral) ; peak plasma concentrations within 1-3 hour.
|6. DOSAGE (DOSING INFORMATION) – MEBEVERINE|
|135 mg 3 times daily, preferably 20 minutes before meals. When the desired effect has been obtained the dosage may be reduced gradually. At least for 6 weeks.
|7. HALF LIFE (DURATION OF ACTION) – MEBEVERINE|
|about 2 hours.
|8. ADVERSE EFFECTS OR SIDE EFFECTS – MEBEVERINE|
|Side effects may include :
|9. CONTRAINDICATIONS – MEBEVERINE|
|Neonates and children under 2 years , lactation.|
|10. DRUG INTERACTIONS – MEBEVERINE|
|Before using this medication, tell your doctor or pharmacist of all prescription and non-prescription/herbal products you may use, especially of: none known
This information does not contain all possible interactions. Therefore, before using mebeverine, tell your doctor or pharmacist of all the products you use.
|11. EXCRETION – MEBEVERINE|
|The urinary excretion of mebeveinr acid within the first 4 h after dosing amounted to 67% of the mebeverine dose.(median range : 23 – 107 %)