Indomethacin

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INDOMETHACIN

Indomethacin 1+

1.       TYPE OF DRUG- INDOMETHACIN
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). It is thought to work by blocking the action of a certain chemical in the body called prostaglandin.

 

2.       INDICATIONS (USE) – INDOMETHACIN
Indomethacin is used to relieve pain, swelling, and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions.

 

3.       MECHANISM OF ACTION (MOA) – INDOMETHACIN
Indomethacin is a nonselective inhibitor of cyclooxygenase (COX) 1 and 2, enzymes that participate in prostaglandin synthesis from arachidonic acid. Prostaglandins are hormone-like molecules normally found in the body, where they have a wide variety of effects, some of which lead to pain, fever, and inflammation.

Prostaglandins also cause uterine contractions in pregnant women. Indomethacin is an effective tocolytic agent, able to delay premature labor by reducing uterine contractions through inhibition of PG synthesis in the uterus and possibly through calcium channel blockade.

 

4.       ROUTES OF ADMINISTRATION- INDOMETHACIN
Indomethacin is available in 25 mg and 50 mg capsules for oral administration. Indomethacin is promptly and completely absorbed after oral administration.

 

5.       ONSET OF EFFECT OR ACTION- INDOMETHACIN
Some analgesic effect may be felt within 2-4 hr. full anti-inflammatory effect may not be felt for up to 4 weeks.

 

6.     DOSAGE (DOSING INFORMATION) – INDOMETHACIN
50-200mg daily in divided doses with food

 

7.       HALF LIFE (DURATION OF ACTION) – INDOMETHACIN
5 to 10 Hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – INDOMETHACIN
Acid or sour stomach,belching,diarrhea,heartburn,indigestion,nausea,stomach discomfort, upset, or pain,vomiting

 

9.       CONTRAINDICATIONS – INDOMETHACIN- INDOMETHACIN
Suppositories INDOCIN are contraindicated in patients with known hypersensitivity to indomethacin or the excipients. Suppositories INDOCIN should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.

 

10.   DRUG INTERACTIONS – INDOMETHACIN- INDOMETHACIN
Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, “water pills” (diuretics such as furosemide).indomethacindrug label information in our database does not contain a dedicatedsection on drug interactions.

 

11.    EXCRETION- INDOMETHACIN
About 60 percent of an oral dosage is recovered in urine as drug and metabolites (26 percent as indomethacin and its glucuronide), and 33 percent is recovered in feces (1.5 percent as indomethacin). About 99% of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. Indomethacin has been found to cross the blood-brain barrier and the placenta.

 

 

Indomethacin 2

By Medifit Education

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