Hypolipidemics

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HYPOLIPIDEMICS

Hypolipidemics

HYPOLIPIDEMICS – INTRODUCTION

Drugs that lower lipid and lipoproteins levels in the blood are known as hypolipidemic drugs.

Hypolipidemic drug, also called lipid-lowering drug, Simvastatin any agent reduces the level of lipids and lipoproteins (lipid-protein complexes) in the blood. Lipoproteins bind cholesterol and can accumulate in blood vessels. High levels of specific lipoproteins, namely, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), have been associated with an elevated risk of certain forms of cardiovascular disease, including coronary artery disease, heart attack, and stroke.


HYPOLIPIDEMICS – INDICATION

Hypolipidemics are used in the treatment of hyperlipidemias. They are called lipid-lowering drugs.

 

HYPOLIPIDEMICS

 

HYPOLIPIDEMICS – INFORMATION

Drugs that lower lipid and lipoproteins levels in the blood are known as hypolipidemic drugs.

The first measure in controlling hyperlipidemias is dietary restriction. However, if it proves unsatisfactory, hypolipidemic drugs are prescribed.

Hypolipidemic drugs have attracted considerable attention since they prevent cardiovascular diseases by retarding atherosclerosis in hyperlipidemic individuals.

 Lipid transport

  • Carried in plasma in form of lipoproteins, after getting associated with several apolipoproteins.
  • Plasma lipid concentrations are dependent upon the concentration of lipoproteins.
  • Lipoprotein globules consist of core of triglyceride and cholesterol esters. The outer polar layer has phospholipids, apoproteins and free cholesterol.

Divided into 6 classes depending upon particle size and density. These are:

  1. Chylomicrons
  2. Chylomicron remnants
  3. VLDL
  4. IDL
  5. LDL
  6. HDL

 

Causes of Hyperlipidemias:

  1. Primary
  • Genetic
  • Multifactorial

 

b.Secondary

  • Diabetes
  • Smoking
  • Hypertension
  • Nephrotic syndrome
  • Alcoholism
  • Drugs

 

Types of Hyperlipidemias

  • Type 1 (Familial Hyperchylomicronemias)(mainly increased VLDL levels)
  • Type 11A (Familial Hypercholesterolemia) (mainly increased LDL levels)
  • Type 11B (Familial Combined Hyperlipidemias) (mainly increased LDL and VLDL levels)
  • Type 111 (Familial Dysbetalipoproteinemias) (mainly increased VLDL levels)
  • Type IV (Familial Hypertriglyceridemia) (mainly increased VLDL levels)
  • Type V(Familial Mixed Hypertriglyceridemia) (mainly increased LDL and VLDL levels)

Hypolipidemics 1

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