HYOSCINE BUTYL BROMIDE
|1. TYPE OF DRUG – HYOSCINE BUTYL BROMIDE|
|Hyoscine butylbromide, also known as scopolamine butylbromide.
|2. INDICATIONS (USE) – HYOSCINE BUTYL BROMIDE|
|Hyoscine is used to treat a number of problems.
It is a direct relaxant of smooth muscle, such as is found in the gut (intestine) and bladder and/or tubes leading to the outside (the genito-urinary tract), and is sometimes known as an antispasmodic, antimuscarinic or anticholinergic drug.
It is used to relieve cramps in the stomach, intestine and genito-urinary tract, and other conditions characterised by spasm of the smooth muscles found in these areas.
In general this drug is used to manage the symptoms of irritable bowel syndrome, a common intestinal condition which causes spasm and pain in the intestine, as well as stomach pain, persistent diarrhoea (sometimes alternating with periods of constipation) and wind (flatulence). Other uses include treatment of spasms in the genito-urinary tract. Injections of hyoscine are also used to prevent muscle spasm during diagnostic procedures (such as inserting an endoscope down the gullet) or for the treatment of short-term spasms of the gall bladder (biliary colic) or the tubes connecting the kidneys to the bladder, called the ureter.
|3. MECHANISM OF ACTION (MOA) – HYOSCINE BUTYL BROMIDE|
|Hyoscine N-butylbromide is a competitive antagonist of the actions of acetylcholine and other muscarinic agonist. The drug is devoid of central nervous actions. The receptors affected by the drug are those of the peripheral structures that are either stimulated or inhibited by muscarine; such as exocrine glands and smooth and cardiac muscle. Cholinergic nerve stimulations are also inhibited but less readily than are responses to injected choline esters.
Depending on the dose, hyoscine N-butylbromide may inhibit the secretions of the respiratory tract, GIT, and sweat glands; it may reduce the motility and tone in the GIT, ureter, urinary bladder and biliary tract.
|4. ROUTES OF ADMINISTRATION- HYOSCINE BUTYL BROMIDE|
|IV, PO, IM, SC
|5. ONSET OF EFFECT OR ACTION- HYOSCINE BUTYL BROMIDE|
|Within 2 hours.
|6. DOSAGE (DOSING INFORMATION) – HYOSCINE BUTYL BROMIDE|
|10 -20 mg 3-5 time daily , IM or IV 20 -40 mg 3-5 times
|7. HALF LIFE (DURATION OF ACTION) – HYOSCINE BUTYL BROMIDE|
|Up to 10 hours.
|8. ADVERSE EFFECTS OR SIDE EFFECTS – HYOSCINE BUTYL BROMIDE|
|9. CONTRAINDICATIONS – HYOSCINE BUTYL BROMIDE|
|Myasthenia gravies, megacolon, hypersensitivity to drug contents, narrow angle glaucoma, prostate hypertrophy with urinary retention, mechanical stenosis in the GI tract, tachycardia.
|10. DRUG INTERACTIONS – HYOSCINE BUTYL BROMIDE|
|The anticholinergic effect of drugs such as tricyclic antidepressants, antihistamines, quinidine, amantadine, disopyramide and other anticholinergics (e.g. tiotropium, ipratropium) may be intensified by Hyoscine-N-butylbromide. Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract. The tachycardic effects of beta-adrenergic agents may be enhanced by Hyoscine-N- butylbromide
|11. EXCRETION- HYOSCINE BUTYL BROMIDE|
|Renal (50%) and fecal.