Granular cell myoblastoma
GRANULAR CELL MYOBLASTOMA
GRANULAR CELL MYOBLASTOMA DEFINATION
Granular cell myoblastoma are benign neoplastic conditions, which are recently being termed as “granular cell tumors” and these are exceptionally rare lesions of the oral cavity.
GRANULAR CELL MYOBLASTOMA CLINICAL FEATURE:
Age: Granular cell myoblastoma usually arises in the adult people between the ages of 30 to 60 years.
Sex: Both sexes are affected with almost equal frequency
Site: Intraorally tongue is most frequently affected, other sites include-lips, floor of the mouth, gingiva, palates and Uvula, etc.
GRANULAR CELL MYOBLASTOMA PRESENTATION:
- The lesion clinically presents a slow enlarging, painless, well-circumscribed lump or mass on the dorsum of the tongue, just beneath the covering epithelium.
- On palpation the neoplasm reveals a firm, nodular growth, which is nonmovable
- The overlying covering epithelium usually appears normal and sometimes it exhibits a yellow or orange tinge.
- Multiple lesions sometimes can develop on the tongue.
GRANULAR CELL MYOBLASTOMA HISTOPATHOLOGY:
- The Unencapsulated neoplasm consists of diffuse sheets of large, oval or polygonal cells, with distinct cytoplasmic membrane.
- These neoplastic cells are often seen to be lying in continuity with the muscle fibers in some cases or with the peripheral myelinated nerves in other cases.
- The cell cytoplasm usually contain large number of discrete, punctate, eosinophilic granules.
- The granular cells often extend up-word toward the epithelium and are present between the rete pegs.
- The cells however are always histologically normal appearing and there is no sign of atypia or dysplasia.
GRANULAR CELL MYOBLASTOMA DIFFERENTIAL DIAGNOSIS:
- Epidermoid carcinoma
- Salivary gland neoplasm
GRANULAR CELL MYOBLASTOMA TREATMENT: