Furazolidone

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FURAZOLIDONE

Furazolidone 2

1.       TYPE OF DRUG – FURAZOLIDONE
Furazolidone is a nitrofuran antibacterial agent.

 

2.       INDICATIONS (USE) – FURAZOLIDONE
This medication is used in the treatment of diarrhea or enteritis caused by bacteria. It may also be useful in treating traveler’s diarrhea, typhoid fever, cholera and salmonella infections.

 

3.       MECHANISM OF ACTION (MOA) – FURAZOLIDONE
Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.

 

4.       ROUTES OF ADMINISTRATION- FURAZOLIDONE
Suspension, Tablet

 

5.       ONSET OF EFFECT OR ACTION- FURAZOLIDONE
Absorption:

Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration

Metabolism:

Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Two major metabolites are produced: 3-amino-2-oxazolidone (AOZ) or beta-hydroxyethylhydrazine (HEH). AOZ is responsible for monoamine oxidase inhibition. Detoxification and elimination of the drug is done primarily by conjugation with glutathione.

6.     DOSAGE (DOSING INFORMATION) – FURAZOLIDONE
Oral

Giardiasis, cholera & other GI infections.

Adult: 100mg 4 times daily. Usual duration: 2-5 days, up to 7 days in some patients or 10 days for giardiasis.

Child: 1.25mg/kg four times daily, usually given for 2-5 days or up to ten days for giardiasis.

 

7.       HALF LIFE (DURATION OF ACTION) – FURAZOLIDONE
10 minutes

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – FURAZOLIDONE
Headache, stomach upset, nausea, vomiting, dizziness or weakness may occur especially the first several days as your body adjusts to the medication. If any of these effects become bothersome or severe, inform your doctor. Notify your doctor if you develop: a fever, skin rash, itching, muscle aches, flushing, breathing trouble. This medication may cause the urine to turn brown in color. Do not be alarmed. Expect this effect. If you notice other effects not listed above, contact your doctor or pharmacist.

 

9.       CONTRAINDICATIONS – FURAZOLIDONE
The medical considerations/contraindications included have been selected on the basis of their potential clinical significance (reasons given in parentheses where appropriate)— not necessarily inclusive (» = major clinical significance).

 

10.   DRUG INTERACTIONS – FURAZOLIDONE
This drug should not be used with the following medications because very serious interactions may occur: apraclonidine, brimonidine, bethanidine, bupropion, buspirone, carbamazepine, dextromethorphan, entacapone, herbal products (e.g., ma huang), indoramin, meperidine, papaverine, sibutramine, SSRI antidepressants (e.g., fluoxetine, citalopram), sympathomimetics (e.g., methylphenidate, ephedrine), tolcapone, tricyclic antidepressants (e.g., amitriptyline, doxepin), “triptans” (e.g., sumatriptan, zolmitriptan). If you are currently using any of these medications, tell your doctor or pharmacist before starting furazolidone.

 

11.     EXCRETION- FURAZOLIDONE
excreted in the urine within 12 hr

 

 

Furazolidone 1

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