Fluticasone Propionate

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Fluticasone Propionate

Fluticasone propionate 2

1.       TYPE OF DRUG-Fluticasone Propionate
Steroid.

 

2.       INDICATIONS (USE)-Fluticasone Propionate
Perennial nonallergic rhinitis.

 

3.       MECHANISM OF ACTION (MOA)-Fluticasone Propionate
Fluticasone propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. Fluticasone propionate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor that is 18 times that of dexamethasone, almost twice that of beclomethasone-17-monopropionate (BMP), the active metabolite of beclomethasone dipropionate, and over 3 times that of budesonide.

 

4.       ROUTES OF ADMINISTRATION-Fluticasone Propionate
Fluticasone is Nasal spray.

 

5.       ONSET OF EFFECT OR ACTION-Fluticasone Propionate
onset of action of fluticasone propionate aqueous nasal spray (FPANS) on mediator release and eosinophil accumulation in nasal secretions and on nasal symptoms of patients with seasonal allergic rhinitis after nasal allergen challenge (NAC).
6.    DOSAGE (DOSING INFORMATION)-Fluticasone Propionate
Adult:

Initially 2 sprays in each nostril once daily or 1 spray in each nostril twice daily (AM and PM). Maintenance: may reduce to 1 spray in each nostril daily. Max total daily doses: 2 sprays in each nostril (200mcg/day).

Children:

4yrs: not established. 4yrs: initially 1 spray in each nostril once daily; may increase to 2 sprays in each nostril once daily. Maintenance: 1 spray in each nostril once daily. Max total daily doses: 2 sprays in each nostril (200mcg/day).

 

7.       HALF LIFE (DURATION OF ACTION)-Fluticasone Propionate
Approximately 7.8 hours.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS-Fluticasone Propionate
  • headache,
  • sore throat,
  • nosebleeds,
  • nasal burning or nasal irritation,
  • nausea,
  • vomiting,
  • asthma symptoms, or.
  • cough.

 

9.       CONTRAINDICATIONS-Fluticasone Propionate
FLONASE (fluticasone propionate) Nasal Spray is contraindicated in patients with a hypersensitivity to any of its ingredients.

 

10.   DRUG INTERACTIONS-Fluticasone Propionate
Avoid ritonavir. Caution with potent CYP3A4 inhibitors (eg, ketoconazole).

 

11.   EXCRETION-Fluticasone Propionate
Less than 5% of the oral dose was excreted in the urine as metabolites. The rest of the dose is excreted in the feces and parent drug and metabolites.

 

 

Fluticasone propionate 1

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