Etoricoxib

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ETORICOXIB

Etoricoxib 2

1.       TYPE OF DRUG-ETORICOXIB
Etoricoxib is a medicine called a non-steroidal anti-inflammatory drug. It is also known as an ‘NSAID’.

 

2.       INDICATIONS (USE)- ETORICOXIB
For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.

 

3.       MECHANISM OF ACTION (MOA)- ETORICOXIB
COX-2 selective inhibitor (“coxib”), etoricoxib selectively inhibits isoform 2 of the enzyme cyclooxygenase (COX-2). It has approximately 106-fold selectivity for COX-2 inhibition over COX-1. This reduces the generation of prostaglandins (PGs) from arachidonic acid. Among the different functions exerted by PGs, their role in the inflammation cascade should be highlighted.

COX-2 selective inhibitors show less activity on COX-1 compared to traditional non-steroidal anti-inflammatory drugs (NSAID). This reduced activity is the cause of reduced gastrointestinal side effects, as demonstrated in several large clinical trials performed with different coxibs.

 

4.       ROUTES OF ADMINISTRATION- ETORICOXIB
Oraly Administration

 

5.       ONSET OF EFFECT OR ACTION- ETORICOXIB
It has rapid absorption leading to rapid onset of action. It is well absorbed with maximum plasma concentrations one hour after dosing so you should see an effect by then or soon after that.

 

6.      DOSAGE (DOSING INFORMATION)- ETORICOXIB
Minimum dosage orally is 60 mg once daily as is given in OA. In RA 90 mg is given once daily.for acute gouty arthritis and acute pain up to a maximum of 120 mg can be given once daily.

 

7.       HALF LIFE (DURATION OF ACTION)- ETORICOXIB
22 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS- ETORICOXIB
·         allergic reactions including rash, itching and hives

·         severe skin reactions, which may occur without warning

·         taste alteration

·         wheezing

·         insomnia

·         anxiety

·         drowsiness

·         mouth ulcers

·         diarrhoea

·         severe increase in blood pressure

·         confusion

·         hallucinations

·         platelets decreased

 

9.       CONTRAINDICATIONS- ETORICOXIB
Active peptic uncler,breast-feeding,children under 16 years of age,inflammatory bowel disease,moderate to serverely decreased kidney function,asthma,rhinitis,nasal polyps,angioedema or ueticaria following NSAIDs,pregnancy,severe heart failure,severely decreased liver function.

 

10.   DRUG INTERACTIONS- ETORICOXIB
Other NSAIDs as this may increase the risk of side effects on the stomach and intestines.Warfarin.regularly moniter INR diuretics and anti-hypertensives enalapril,captopril,cyclosporine.

 

11.    EXCRETION- ETORICOXIB
Etoricoxib is well absorbed, is metabolized extensively via oxidation (6′-methyl oxidation >1′-N-oxidation), and the metabolites are excreted largely in the urine.

 

 

Etoricoxib 1

By Medifit Education

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