Erythromycin

You are here: Home / Erythromycin

 

 

 

 

 Erythromycin

erythromycin-2

1.       TYPE OF DRUG- Erythromycin
Erythromycin is an antibiotic.
2.       INDICATIONS (USE)- Erythromycin
For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires’ disease caused by Legionella pneumophila.
3.       MECHANISM OF ACTION (MOA)- Erythromycin
Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.
4.       ROUTES OF ADMINISTRATION- Erythromycin
Oral
5.       ONSET OF EFFECT OR ACTION- Erythromycin
Within 2-4 hours.
  1. DOSAGE (DOSING INFORMATION)- Erythromycin
Adults

The usual dosage of Erythromycin Base Filmtab is one 250 mg tablet four times daily in equally spaced doses or one 500 mg tablet every 12 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. However, twice-a-day dosing is not recommended when doses larger than 1 g daily are administered.

 

Children

Age, weight, and severity of the infection are important factors in determining the proper dosage. The usual dosage is 30 to 50 mg/kg/day, in equally divided doses. For more severe infections this dosage may be doubled but should not exceed 4 g per day.

7.       HALF LIFE (DURATION OF ACTION)- Erythromycin
6-12 hours
8.       ADVERSE EFFECTS OR SIDE EFFECTS – Erythromycin
erythromycin,hearing loss,mild diarrhea; or. nausea, vomiting, stomach pain
9.       CONTRAINDICATIONS – Erythromycin
Hypersensitivity.
10.   DRUG INTERACTIONS – Erythromycin
Theophylline : increased theophylline side effects.Carbamazepine : carbamazepine blood levels.
  1. EXCRETION- Erythromycin
‎bile

erythromycin-1