Drotaverine

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By Medifit Education

 

DROTAVERINE

Drotaverine 2

1.       TYPE OF DRUG-DROTAVERINE
DROTAVERINE is an antispasmodic drug.

 

2.       INDICATIONS (USE)- DROTAVERINE
Drotaverin (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.

Smooth muscle spasm, Gastrointestinal colic pain, Renal colic pain, Dysmenorrhoea, Uterine neck spasm.

 

3.       MECHANISM OF ACTION (MOA)- DROTAVERINE
Its antispasmodic effect is mediated via inhibition of phosphodiesterase-IV , specific for smooth muscle. It has rapid and direct action on the smooth muscle spasm and pain.

 

4.       ROUTES OF ADMINISTRATION- DROTAVERINE
Oral and Injectable.

 

5.       ONSET OF EFFECT OR ACTION- DROTAVERINE
30 minutes

 

6.      DOSAGE (DOSING INFORMATION)- DROTAVERINE
Adults-40-80 mg thrice daily.

Children-1-5 years 20 mg 3-4 times daily

6-12 year-40 mg thrice daily

 

7.       HALF LIFE (DURATION OF ACTION)- DROTAVERINE
4 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – DROTAVERINE
It is free from CNS side effects, addiction, dyness of mouth,blurring of vision and blood dyscrasias. Free from gastric irritation.

 

9.       CONTRAINDICATIONS – DROTAVERINE
Glaucoma,paralytic  ileus,benign prostat hyperplasis.

 

10.   DRUG INTERACTIONS – DROTAVERINE
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

 

11.   EXCRETION- DROTAVERINE
‎>50% in urine and ~30% in bile

 

 

Drotaverine 1

By Medifit Education

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