Dicyclomine

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By Medifit Education

 

DICYCLOMINE

Dicyclomine 2

1.       TYPE OF DRUG – DICYCLOMINE
This medication belongs to a group of drugs called anticholinergic (or antimuscarinic)

 

2.       INDICATIONS (USE) – DICYCLOMINE
Dicyclomine is an anticholinergic. It works by blocking a chemical in the smooth muscle of the stomach and intestines, causing them to relax, which reduces cramping.

 

3.       MECHANISM OF ACTION (MOA) – DICYCLOMINE
It relxes the smooth muscles and relives spasm in GI tract and urinary tract. The action is exerted partly due to muscarinic antagonism and partly due to direct action on plain muscle.

 

4.       ROUTES OF ADMINISTRATION – DICYCLOMINE
Orally, Injectable administration

 

5.       ONSET OF EFFECT OR ACTION – DICYCLOMINE
1 to 2 hours

 

6.  DOSAGE (DOSING INFORMATION) – DICYCLOMINE
Adult Dose Initial dose: 20 mg orally four times a day

Maintenance dose: Up to 40 mg orally four times a day, after one week with initial dose

 

7.       HALF LIFE (DURATION OF ACTION) – DICYCLOMINE
4 to 6 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – DICYCLOMINE
Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.

 

9.       CONTRAINDICATIONS – DICYCLOMINE
Obstructive uropathy

Obstructive disease of the gastrointestinal tract

Severe ulcerative colitis (see PRECAUTIONS)

Reflux esophagitis

Unstable cardiovascular status in acute hemorrhage

Glaucoma

Myasthenia gravis

Evidence of prior hypersensitivity to Dicyclomine hydrochloride or other ingredients in this formulation

Infants less than 6 months of age (see WARNINGS and PRECAUTIONS: Information for Patients.)

Nursing Mothers

 

10.   DRUG INTERACTIONS – DICYCLOMINE
Amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.

 

11.  EXCRETION – DICYCLOMINE
The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).

 

Dicyclomine 1

By Medifit Education

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