|1. TYPE OF DRUG – DICYCLOMINE|
|This medication belongs to a group of drugs called anticholinergic (or antimuscarinic)
|2. INDICATIONS (USE) – DICYCLOMINE|
|Dicyclomine is an anticholinergic. It works by blocking a chemical in the smooth muscle of the stomach and intestines, causing them to relax, which reduces cramping.
|3. MECHANISM OF ACTION (MOA) – DICYCLOMINE|
|It relxes the smooth muscles and relives spasm in GI tract and urinary tract. The action is exerted partly due to muscarinic antagonism and partly due to direct action on plain muscle.
|4. ROUTES OF ADMINISTRATION – DICYCLOMINE|
|Orally, Injectable administration
|5. ONSET OF EFFECT OR ACTION – DICYCLOMINE|
|1 to 2 hours
|6. DOSAGE (DOSING INFORMATION) – DICYCLOMINE|
|Adult Dose Initial dose: 20 mg orally four times a day
Maintenance dose: Up to 40 mg orally four times a day, after one week with initial dose
|7. HALF LIFE (DURATION OF ACTION) – DICYCLOMINE|
|4 to 6 hours
|8. ADVERSE EFFECTS OR SIDE EFFECTS – DICYCLOMINE|
|Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.
|9. CONTRAINDICATIONS – DICYCLOMINE|
Obstructive disease of the gastrointestinal tract
Severe ulcerative colitis (see PRECAUTIONS)
Unstable cardiovascular status in acute hemorrhage
Evidence of prior hypersensitivity to Dicyclomine hydrochloride or other ingredients in this formulation
Infants less than 6 months of age (see WARNINGS and PRECAUTIONS: Information for Patients.)
|10. DRUG INTERACTIONS – DICYCLOMINE|
|Amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.
|11. EXCRETION – DICYCLOMINE|
|The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).