Cholera Vaccine

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By Medifit Education

 

CHOLERA VACCINE

Cholera Vaccine 2

1.       TYPE OF DRUG – CHOLERA VACCINE
Immunizing agent

 

2.       INDICATIONS (USE) – CHOLERA VACCINE
Active immunization against cholera is indicated only for individuals traveling to or residing in countries where cholera is endemic or epidemic.

 

3.       MECHANISM OF ACTION (MOA) – CHOLERA VACCINE
Inactivated V. cholerae 01 present in cholera vaccine promote the production of vibriocidal antibodies.

 

4.       ROUTES OF ADMINISTRATION – CHOLERA VACCINE
Injection

 

5.       ONSET OF EFFECT OR ACTION – CHOLERA VACCINE
6.      DOSAGE (DOSING INFORMATION) – CHOLERA VACCINE
For primary immunisation of adults or children of 14 years or older, two (2) doses of 1 mL are given by subcutaneous injection 14 days apart. It may be expected to confer immunity in about 50% of subjects for up to six months, but persons at risk should be aware of the importance of good hygiene and safe drinking water in the prevention of cholera. The dose for children over 1 year old should be between 0,1 mL and 1 mL in proportion to body mass. Further doses may be given at 6 monthly intervals if required. Not recommended for children less than 1 year old. Sterilise the rubber closure with tincture of iodine and shake vial vigorously before use.

 

7.       HALF LIFE (DURATION OF ACTION) – CHOLERA VACCINE
3 to 6 months

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – CHOLERA VACCINE
Local reactions manifested by erythema, induration, pain, and tenderness at the site of injection occur in most recipients, and such local reactions may persist for a few days.

Recipients frequently develop malaise, headache, and mild-to-moderate temperature elevations which may persist for 1 to 2 days.

 

9.       CONTRAINDICATIONS – CHOLERA VACCINE
Not recommended for patients with an acute infections or for children less than one year old. Should be used with great caution if there has been a history of allergy to previous vaccination.

 

10.   DRUG INTERACTIONS – CHOLERA VACCINE
Some data suggest that administration of cholera and yellow fever vaccines within three weeks of each other may result in decreased levels of antibody response to both vaccines as compared with administration at longer intervals. However, there is no evidence that protection to either disease is diminished following simultaneous administration.

 

11.     EXCRETION – CHOLERA VACCINE
The incubation period is usually 2-5 days. However, it can sometimes be a few hours. 75% of those infected are asymptomatic.However, those who remain asymptomatic excrete the organism for 7 to 14 days.

 

Cholera Vaccine 1

By Medifit Education

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