Chlorzoxazone

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CHLORZOXAZONE

chlorzoxazone 1

1.       TYPE OF DRUG – CHLORZOXAZONE
It works by blocking nerve impulses (or pain sensations) that are sent to your brain.

 

2.       INDICATIONS (USE) – CHLORZOXAZONE
Chlorzoxazone is used to treat muscle spasms/pain. It is usually used along with rest, physical therapy, and other treatment. It works by helping to relax the muscles.

 

3.       MECHANISM OF ACTION (MOA) – CHLORZOXAZONE
Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation.

 

4.       ROUTES OF ADMINISTRATION- CHLORZOXAZONE
Oral  administration

 

5.       ONSET OF EFFECT OR ACTION
The plasma elimination half-life is about 1 hour for chlorzoxazone.

 

6.  DOSAGE (DOSING INFORMATION) – CHLORZOXAZONE
Dose for Adults  250 to 750 mg orally 3 to 4 times a day , children 5 -12 yrs 50 – 100 mg

 

7.       HALF LIFE (DURATION OF ACTION) – CHLORZOXAZONE
6 to 8 hrs.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – CHLORZOXAZONE
Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction, over-stimulation.

 

9.       CONTRAINDICATIONS – CHLORZOXAZONE
Chlorzoxazone is contraindicated in patients with known intolerance to the drug.  This medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

10.   DRUG INTERACTIONS – CHLORZOXAZONE
Before using chlorzoxazone, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorzoxazone.

 

11.  EXCRETION- CHLORZOXAZONE
Urinary excretion of 6-hydroxychlorzoxazone is an index of CYP2E1 activity in vivo.

 

chlorzoxazone 2

By Medifit Education

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