Cefotaxime

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 Cefotaxime

Cefotaxime 1

1.       TYPE OF DRUG- Cefotaxime
Cefotaxime (INN) is a third-generation cephalosporin antibiotic.

 

2.       INDICATIONS (USE)- Cefotaxime
Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.

 

3.       MECHANISM OF ACTION (MOA)- Cefotaxime
The bactericidal activity of cefotaxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotaxime shows high affinity for penicillin-binding proteins in the cell wall including PBP Ib and PBP III.

 

4.       ROUTES OF ADMINISTRATION- Cefotaxime
Injection

 

5.       ONSET OF EFFECT OR ACTION- Cefotaxime
Within mins.

 

6.     DOSAGE (DOSING INFORMATION)- Cefotaxime
Adult

Gonococcal Urethritis/Cervicitis

0.5 g IM once

Gonorrhea, Rectal

Men: 1 g IM once

Women: 0.5 g IM once

Infections Caused by Susceptible Organisms

Uncomplicated: 1 g IV or IM q12hr

Moderate to severe: 1-2 g IV or IM q8hr

More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr

Life-threatening: 2 g IV q4hr; not to exceed 12 g/day

Preparation for Surgery

Prophylaxis of surgical infection

1 g IM/IV once 30-90 minutes before start of procedure

Usual dosage range in children

0-1 week: 50 mg/kg IV q12hr

1-4 weeks: 50 mg/kg IV q8hr

1 month-12 years: 50-180 mg/kg/day IV divided q4-6hr

>12 years: 1-2 g IV/IM q4-8hr

 

7.       HALF LIFE (DURATION OF ACTION)- Cefotaxime
8-12 hrs.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – Cefotaxime
  • diarrhea that is watery or bloody
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness
  • uneven heartbeats
  • fever, chills, body aches, flu symptoms
  • easy bruising or bleeding, unusual weakness

 

9.       CONTRAINDICATIONS – Cefotaxime
Hypersensitivity to cephalosporins.

 

10.   DRUG INTERACTIONS – Cefotaxime
Probenecid decreases cefotaxime elimination.

Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.

 

11.    EXCRETION- Cefotaxime
Approximately 20-36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15-25% as the desacetyl derivative, the major metabolite.

 

Cefotaxime 2

 

By Medifit Education

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