Cefadroxil

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Cefadroxil

Cefadroxil 1

1.       TYPE OF DRUG- Cefadroxil
Cefadroxil is a antibiotic.

 

2.       INDICATIONS (USE)- Cefadroxil
For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes

 

3.       MECHANISM OF ACTION (MOA)- Cefadroxil
Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.

 

4.       ROUTES OF ADMINISTRATION- Cefadroxil
Oral.

 

5.       ONSET OF EFFECT OR ACTION- Cefadroxil
30-60 minutes.

 

6. DOSAGE (DOSING INFORMATION)- Cefadroxil
Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.

 

7.       HALF LIFE (DURATION OF ACTION)- Cefadroxil
1.5 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – Cefadroxil
The most common side effects of cefadroxil are diarrhea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include rashes, hives, and itching.

 

9.       CONTRAINDICATIONS – Cefadroxil
Hypersensitivity to cephalosporins

 

10.   DRUG INTERACTIONS – Cefadroxil
Probenecid increases the blood levels of many cephalosporins. Concurrent use of furosemide increases the renal toxicity. Cefadroxil potentiates nephro toxicity of aminoglycosides.

 

11. EXCRETION- Cefadroxil
Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk.

 

 

Cefadroxil 2

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