BRAIN POWER/ FUNCTIONS
Medifit Education clearly explains the use of Anabolic steroids on neuroprotection and brain function along with brain cells aging in old age. Research available is very less and more studies are required to know the exact mechanism and role of Anabolic steroids in brain cells protection and recovery.
Does Anabolic steroids causes growth of brain cells & prevents Alzheimer’s disease and dementia?
Research reveal that, Anabolic steroids abusers damage their brain cells and on the contrary, patients administered with medical doses of Anabolic Steroids (non-abusers) prevents brain aging and improves neuroprotection.
Scientists are still learning about how anabolic steroids affect the brain, and in turn, behaviour. Parts of the brain that influence your moods and are involved in learning and memory are called the limbic system. Anabolic steroids act in the limbic system. In animals, they have been shown to impair learning and memory.
However, it is important to note that these changes generally became more prominent as the doses are increased, but they do not manifest uniformly among all users of anabolic steroids.
ANDROGENS AND BRAIN
Androgens have an outstanding part in the brain functions. It was showed a
neuroprotective and neuromodulation actions of AAS during brain development but also
during brain aging and the important of androgens on the systems involved in cognitive
function, mood disturbances and central drive of sexuality. Androgen receptors are found in
brain regions that are crucial for learning and memory including the hypothalamus, the
hippocampus, prefrontal cortex, and amygdala, but are not found in other cortical regions of
the brain. In these areas the androgens acting on specific nuclear receptors or throughout the
metabolism into neuroactive compounds. The hormone are important during pre- and
perinatal brain development for the formation of sex-specific behavioral. The brain areas
involved in pre and perinatal androgens effects are the same that show functional loss with
aging. Bioavailable testosterone levels decline with age in men and women and numerous
studies suggest a link between testosterone and cognition in men, particularly with aging.
Testosterone supplementation improves spatial cognition and working memory in healthy
older men. Visual-spatial cognition improves in older men with testosterone replacement in a
dose-dependent manner, but similar effects are not found in young men. Testosterone
replacement has few effects in men with low or no testosterone throughout life (congenital
hypogonadism). Lower testosterone levels are associated with a higher risk for Alzheimer’s
Harvard Men’s Health Watch, it was reported that testosterone can also affect men’s cognitive performance. It is known that with age our body’s attributes change a lot and so is the mental function level. With the advancement of age, learning process becomes slow and we often forget the details. These changes lead to “senior moment” in healthy elders and to cognitive impairment and dementia in others.
The study showed that the decline of testosterone level with age and mental functions has some connectivity. For example, higher testosterone levels during midlife are linked with better preservation of tissue in some parts of the brain while in older age, the increased level of the hormone is associated with better performance on cognitive tests.
If this happens then do the treatments use for reducing testosterone can lead to cognitive decline? For answering this simple question three studies had been done and all of them linked impaired performance on cognitive tests with androgen deprivation therapy. The therapy is sometimes used for treating prostate cancer, though the effects are modest only.
The recent study also raised the question that whether testosterone therapy might improve mental function in healthy older men or could be used for those suffering with cognitive impairment. However, the study also warned that high testosterone levels might prove harmful as well. Harvard Men’s Health Watch also suggested that until more research studies were done in this aspect, men should not use testosterone or any other androgen to improve mental function.