Basal Cell Carcinoma
BASAL CELL CARCINOMA
BASAL CELL CARCINOMA DEFINITON
Basal cell carcinoma is a common, locally aggressive, nonmetastasizing malignant neoplasm of the skin, which is usually composed of medullary pattern of basaloid cells.
BASAL CELL CARCINOMA CAUSES:
Age: Basal cell carcinoma develops mostly in middle aged people, preferably in the 4th decade of life.
Sex: Males are most commonly affected than females
- The neoplasm initiates as a slow growing, slightly elevated, small nodule.
- It eventually develops into a central, crusted ulcer with an elevated, smooth rolled border.
- The synonym “rodent ulcer” is given to this tumor since it makes a slow but relentless progress and increase in size by invading and destroying the adjoining tissues.
- Histopathology basal cell carcinoma is characterized by neoplastic proliferation of basaloid epithelial cells in the form of multiple solid islands.
- The cells in the periphery of the tumor islands are columnar in shape and they often resemble basal layer of the oral epithelium with hyperchromatic nuclei.
- The fibrous connective tissue stroma reveals varying degrees of cellularity and it contains large number of elastic fibers.
BASAL CELL CARCINOMA DIFFERENTIAL DIAGNOSIS:
The following lesions are included in the differential diagnosis of basal cell carcinoma:
- Salivary gland neoplasms
- Squamous cell carcinoma.
BASAL CELL CARCINOMA TREATMENT:
Surgical Excision or electrocautery along with radiotherapy is the treatment of choice.