Azithromycin

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 Azithromycin

Azithromycin 1

1.       TYPE OF DRUG- Azithromycin
Azithromycin is an antibiotic

 

2.       INDICATIONS (USE)- Azithromycin
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal

 

3.       MECHANISM OF ACTION (MOA)- Azithromycin
Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells.

 

4.       ROUTES OF ADMINISTRATION- Azithromycin
Oral ,Injection.

 

5.       ONSET OF EFFECT OR ACTION- Azithromycin
Within 1-2 hrs.

 

6. DOSAGE (DOSING INFORMATION)- Azithromycin
Oral

Skin and soft tissue infections

Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on the 1st day followed by 250 mg once daily for 4 days.

Child: >6 mth: 10 mg/kg; 15–25 kg: 200 mg; 26–35 kg: 300 mg; 36–45 kg: 400 mg. Doses to be taken once daily for 3 days

 

Oral

Respiratory tract infections

Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on the 1st day followed by 250 mg once daily for 4 days.

Child: >6 mth: 10 mg/kg; 15–25 kg: 200 mg; 26–35 kg: 300 mg; 36–45 kg: 400 mg. Doses to be taken once daily for 3 days

 

Oral

Uncomplicated genital infections due to Chlamydia trachomatis

Adult: 1 g as a single dose.

 

Oral

Uncomplicated gonorrhoea

Adult: 2 g as a single dose.

 

Oral

Prophylaxis of disseminated Mycobacterium avium complex (MAC) infections

Adult: 1.2 g once every wk. For treatment or secondary prophylaxis: 500 mg once daily with other antimycobacterials.

Child: >6 mth: 10 mg/kg once daily for 3 days.

 

Oral

Granuloma inguinale

 

Adult: Initially, 1 g followed by 500 mg daily. Alternatively, 1 g once a wk for at least 3 wk, until all lesions have completely healed.

 

Intravenous

Active immunisation against typhoid fever caused by Salmonella typhi

Adult: 500 mg once daily for 7 days.

 

7.       HALF LIFE (DURATION OF ACTION)- Azithromycin
68 hours

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – Azithromycin
Mild diarrhea, vomiting, constipation

Stomach pain or upset

Dizziness, tired feeling, mild headache

Nervous feeling, sleep problems (insomnia)

Vaginal itching or discharge

Mild rash or itching

Ringing in your ears, problems with hearing or

Decreased sense of taste or smell.

 

9.       CONTRAINDICATIONS – Azithromycin
Hypersensitivity

 

10.   DRUG INTERACTIONS – Azithromycin
Antacids containing aluminium and magnesium salts reduce rate of absorption. Increased risk of ergot toxicity.

Potentially Fatal

Increased serum concentrations of digoxin and ciclosporin.

 

11. EXCRETION- Azithromycin
Biliary excretion of azithromycin, predominantly as unchanged drug, is a major route of elimination.

 

Azithromycin 2

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