Antiarthritics

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By Medifit Education

 

ANTIARTHRITICS

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 ANTIARTHRITICS – INTRODUCTION:

This abbreviation stands for non-steroidal anti-inflammatory drugs, which are medications such as Ibufprofen that are used to control pain and inflammation. Most may be purchased over the counter. One of their major side effects is that they decrease the effect of the normal blood clotting factors in blood.

 ANTIARTHRITICS – INDICATION:

NSAIDs are used for treatment of inflammation of Arthritis.

The clinical use of corticosteroids and second-line antirheumatic drugs provides relief in many patients but is associated with short-term and long-term toxicity. The beneficial effects are evident but are not well understood, particularly for the second-line agents

 

  ANTIARTHRITICS – INFORMATION:

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well asbeing immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisoneacetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g.betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroidshave side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataractformation.There are other antiinflammatory drugs that are non.

 

The clinical use of corticosteroids and second-line ant rheumatic drugs provides relief in many patients but is associated with short-term and long-term toxicity. The beneficial effects are evident but are not well understood, particularly for the second-line agents. Rheumatoid arthritis is associated with abnormalities in macrophage, lymphocyte, and fibroblast functions. Corticosteroids and second-line agents appear to alter many of these responses (Table 2). Effects on macrophage and other antigen processing and phagocytic cells are common, but T- and B-lymphocytes also may be affected. Some of these agents have direct anti-inflammatory properties by inhibiting prostaglandin or leukotriene synthesis. A few are able to inhibit fibroblast proliferation and secretion of inflammatory mediators. Many other activities are possible. Understanding pharmacokinetics also should assist in determining dosing, possible consequences of other disorders, and predicting duration of acute effects. A better understanding of the disease process in rheumatoid arthritis and other disorders treated with these agents will lead to the better therapeutic approaches and, it is hoped, the discovery of more specific and less toxic agents.

 

Side Effects

  • Conditions of Excess Stomach Acid SecretionLess
  • DiarrheaLess
  • Feel Like Throwing UpLess
  • HeartburnLess
  • Stomach Cramps

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By Medifit Education

www.themedifit.in