ANTIANGINALS – INTRODUCTION:
Antiangina drugs are medicines that relieve the symptoms of angina pectoris (severe chest pain).
ANTIANGINALS – INDICATION:
An antianginal is any drug used in the treatment of angina pectoris, a symptom of ischaemic heart disease.
ANTIANGINALS – INFORMATION:
Drugs that reduce myocardial oxygen demand are commonly used to prevent and treat episodes of ischemic pain associated with fixed stenotic lesions (i.e., chronic stable angina). Some of these drugs reduce oxygen demand by decreasing heart rate (decreased chronotropy) and contractility (decreased inotropy), while other drugs reduceafterload and or preload on the heart. Afterload and preload reducing drugs act by dilating peripheral arteries and veins. Direct vasodilation of the coronary arteries is ineffective as a therapeutic approach and may actually worsen the ischemia by producing coronary vascular steal.
Antianginal drugs are used to manage angina by either improving perfusion of the myocardium, reducing the metabolic demand of the heart, or both.
Two of the main groups of antianginal drugs are organic nitrates and calcium antagonists. They are vasodilators and improve myocardial perfusion, and reduced metabolic demand of the myocardium.
Beta-adrenoreceptor antagonists slow the heart rate therefore reduces metabolic demand of the heart.