|1. TYPE OF DRUG-Ambroxol|
|Ambroxol is a clinically proven systemically active mucolytic agent.
|2. INDICATIONS (USE)-Ambroxol|
|Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Mucobrox, Mucol, Lasolvan, Mucoangin, Surbronc, Ambolar, and Lysopain.
|3. MECHANISM OF ACTION (MOA)-Ambroxol|
|Ambroxol is a metabolite of bromhexine and is used similarly as a mucolytic.
|4. ROUTES OF ADMINISTRATION-Ambroxol|
|tablets & Syrup
|5. ONSET OF EFFECT OR ACTION-Ambroxol|
|Oral : after about 30 minutes.
|6. DOSAGE (DOSING INFORMATION)-Ambroxol|
|Adults: daily dose of 30 mg (one Ambroxol tablet ) to 120 mg (4 Ambroxol tablets) taken in 2 to 3 divided doses
Children up to 2 years: half a teaspoonful Ambroxol syrup twice daily
Children 2 – 5 years: half a teaspoonful Ambroxol syrup 3 times daily
Children over 5 years: One teaspoonful Ambroxol syrup 2-3 times daily
|7. HALF LIFE (DURATION OF ACTION)-Ambroxol|
|8. ADVERSE EFFECTS OR SIDE EFFECTS-Ambroxol|
|Occasional gastrointestinal side effects may occur but these are normally mild.
|There are no absolute contraindications but in patients with gastric ulceration relative caution should be observed.
|10. DRUG INTERACTIONS-Ambroxol|
|When concurrently used with antibiotics i.e. amoxicilline, cefuroxime, erythromycin, doxycyclineleads to higher antibiotic concentration in the lung issue.
|The drug is metabolized in the liver by conjugation with the formation of pharmacologically inactive metabolites. About 90% of ambroxol excreted in the urine: 90% of them in the form of metabolites and 10% unchanged.