Aceclofenac

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ACECLOFENAC

Aceclofenac 2

 

1.       TYPE OF DRUG- ACECLOFENAC
Aceclofenac is a medicine called a non-steroidal anti-inflammatory drug. It is also known as ‘an NSAID’.

 

2.       INDICATIONS (USE) – ACECLOFENAC
It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Acute pain in Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Low back pain, Dental pain, Fracture, and painful Pharyngitis & Tonsillitis

 

3.       MECHANISM OF ACTION (MOA) – ACECLOFENAC
It is an inhibitor cyclooxygenase pathway of prostaglandin synthesis.

 

4.       ROUTES OF ADMINISTRATION – ACECLOFENAC
Aceclofenac film-coated tablets are supplied for oral administration and should be swallowed whole with a sufficient quantity of liquid.

 

5.       ONSET OF EFFECT OR ACTION – ACECLOFENAC
1 hours

 

6.       DOSAGE (DOSING INFORMATION) – ACECLOFENAC
The dose is 100 mg twice daily.

 

7.       HALF LIFE (DURATION OF ACTION) – ACECLOFENAC
12 hours- 24 hours.

 

8.       ADVERSE EFFECTS OR SIDE EFFECTS – ACECLOFENAC
Low back pain is very common complaint in all age groups.gastrointestinal disorders,headache,dizziness,drowsiness,swollen feet/ankels,rash,wheezing/breathlessness,

 

9.       CONTRAINDICATIONS – ACECLOFENAC
Hypersensitivity to Aceclofenac or to any of the excipients. NSAIDS are contraindicated in patients who have previously shown hypersensitivity reactions (e.g. Asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.

 

10.   DRUG INTERACTIONS – ACECLOFENAC
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.

 

11.    EXCRETION – ACECLOFENAC
Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol: Most metabolites are removed in the urine within 24 hours.

 

Aceclofenac 1

 

By Medifit Education

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