|1. TYPE OF DRUG- ACECLOFENAC|
|Aceclofenac is a medicine called a non-steroidal anti-inflammatory drug. It is also known as ‘an NSAID’.
|2. INDICATIONS (USE) – ACECLOFENAC|
|It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Acute pain in Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Low back pain, Dental pain, Fracture, and painful Pharyngitis & Tonsillitis
|3. MECHANISM OF ACTION (MOA) – ACECLOFENAC|
|It is an inhibitor cyclooxygenase pathway of prostaglandin synthesis.
|4. ROUTES OF ADMINISTRATION – ACECLOFENAC|
|Aceclofenac film-coated tablets are supplied for oral administration and should be swallowed whole with a sufficient quantity of liquid.
|5. ONSET OF EFFECT OR ACTION – ACECLOFENAC|
|6. DOSAGE (DOSING INFORMATION) – ACECLOFENAC|
|The dose is 100 mg twice daily.
|7. HALF LIFE (DURATION OF ACTION) – ACECLOFENAC|
|12 hours- 24 hours.
|8. ADVERSE EFFECTS OR SIDE EFFECTS – ACECLOFENAC|
|Low back pain is very common complaint in all age groups.gastrointestinal disorders,headache,dizziness,drowsiness,swollen feet/ankels,rash,wheezing/breathlessness,
|9. CONTRAINDICATIONS – ACECLOFENAC|
|Hypersensitivity to Aceclofenac or to any of the excipients. NSAIDS are contraindicated in patients who have previously shown hypersensitivity reactions (e.g. Asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.
|10. DRUG INTERACTIONS – ACECLOFENAC|
|May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
|11. EXCRETION – ACECLOFENAC|
|Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol: Most metabolites are removed in the urine within 24 hours.