97. Chinese Herbal Medicine For Psoriasis

You are here: Home / 97. Chinese Herbal Medicine For Psoriasis

97. Chinese Herbal Medicine For Psoriasis

 

 

CATEGORY:Alternative Medicines 300 Courses

COURSE NUMBER: 97

FEES: 555/- INR only

CERTIFICATE VALIDITY: Lifetime

CERTIFICATES DELIVERY: In 48 hours

BOOKS/ MANUALS: Pages

Syllabus

Table of contents i
List of figures xi
List of tables xiii
Publications xv
Abbreviations xvii
Summary xix
Chapter 1: Introduction 1
1.1 Overview of the disease 1
1.2 Epidemiology of psoriasis 2
1.2.1 Incidence 2
1.2.2 Prevalence in the world, Australia and China 3
1.3 The cost of prevention & treatment 7
1.3.1 Total cost of psoriasis management 8
1.3.2 Cost of specific interventions 11
1.3.2.1 Topical therapy 11
1.3.2.2 Systemic, phototherapy and biological therapy 11
1.4 Research background 12
1.5 Reviews on herbal medicine (HM) for psoriasis 14
1.6 Significance of the research 15
1.7 Aims of the research 16
1.8 Research questions 17
Chapter 2: The characteristics of psoriasis and related disorders 18
2.1 Pathophysiology of psoriasis 18
2.1.1 Genetics of psoriasis 18
2.1.2 Psoriasis-precipitating factors 19
2.1.3 Main mechanism of psoriasis 22
2.1.4 Histopathological changes 24
2.2 Diagnosis 25
2.2.1 Clinical features 25
2.2.2 Diagnosis and assessment tools 26
2.2.3 Types of psoriasis 27
2.2.4 Differential diagnosis: 31
2.2.5 Comorbidities associated with psoriasis 33
2.3 Therapy 34
2.3.1 Topical treatment 34
2.3.2 Phototherapy and photochemotherapy 38
2.3.3 Systemic and biological treatments 41
Chapter 3: Traditional Chinese Medicine for psoriasis 46
3.1 Introduction 46
3.2 Background of Chinese Herbal Medicine (CHM) 46
3.3 The TCM terms for psoriasis 49
3.3.1 Gan xuan 49
3.3.2 She shi 50
3.3.3 Bai bi 50
3.3.4 Bai ke chuang 50
3.3.5 Song pi xuan 50
3.3.6 Ying qian feng 50
3.4 The TCM aetiology of psoriasis 51
3.4.1 External pathogens 51
3.4.2 Internal damage 51
3.5 The TCM physiology and pathology of psoriasis 52
3.5.1 The physiology and pathology of lung in TCM 52
3.5.2 Physiology and pathology of heart in TCM 53
3.5.3 Physiology and pathology of liver in TCM 53
3.5.4 Physiology and pathology of blood in TCM 53
3.5.5 The pathogenesis of psoriasis in TCM 54
3.6 The TCM diagnosis of psoriasis 54
3.6.1 Clinical symptoms and syndromes in TCM 54
3.6.2 The TCM syndromes seen in psoriasis 55
3.6.3 Contemporary TCM diagnostic criteria in psoriasis 57
3.7 TCM management of psoriasis 58
3.7.1 Treatment based on syndrome differentiation (TSD) and the relevant schools 59
3.7.2 The approach that uses CHM preparations that are specific for the disease (PSD) 66
3.7.3 Acupuncture and the other manual therapies 67
Chapter 4: Methodology for systematic reviews of clinical trials of herbal medicine for psoriasis 70
4.1 Aims 70
4.2 Selection of search terms and search procedure 70
4.2.1 Embase 71
4.2.2 Medline via Pubmed 73
4.2.3 Cochrane Library 74
4.2.4 CNKI 75
4.2.5 CQVIP 77
4.3 Removal of duplicates 80
4.4 Screening and categorization of citations 80
4.5 Exclusion and inclusion criteria 81
4.6 Data extraction 82
4.7 Evaluation of the Methodological Quality of the studies 82
4.8 Data analysis 82
Chapter 5: Results of systematic review of RCTs on internal HM for psoriasis 84
5.1.1 Overall results of searches of databases 84
5.1.1.1 PubMed 84
5.1.1.2 Cochrane library 85
5.1.1.3 Embase 85
5.1.1.4 CQVIP 85
5.1.1.5 CNKI 86
5.1.2 Combination of database retrievals: 87
5.1.3 Screening 87
5.1.4 Evaluation for eligibility: 88
5.1.5 Evaluation of controlled clinical trials for inclusion 89
5.1.5.1 Exclusions based on the intervention (E 9) 89
5.1.5.2 Exclusion of the non-randomisation studies (E 10) 89
5.1.5.3 Exclusions based on trial design (E 11) 89
5.1.6 Summary of the candidate entries for eligibility 90
5.2 Systematic review 1 90
5.2.1 Introduction 90
5.2.2 Method 91
5.2.3 Results 94
5.2.3.1 Description of studies 103
5.2.3.2 Methodological assessment 106

5.2.3.3 Meta-analysis 107
5.2.3.4 Adverse events (AEs) 115
5.2.3.5 Principal herbs used in the studies 116
5.2.4 Discussion 116
5.2.5 Limitations of this review 119
5.2.6 Summary 120
Chapter 6: Results of systematic review of RCTs on external HM for psoriasis 122
6.1 Results of systematic review 2: Single herbs for the external management of psoriasis: A systematic
review with meta-analysis of RCTs 122
6.1.1 Introduction 122
6.1.2 Method 122
6.1.3 Results 125
6.1.4 Methodological assessment 134
6.1.5 Meta-analysis 135
6.1.6 Adverse events (AEs) 139
6.1.7 Summary 139
6.2 Results of systematic review 3: Herbal formula for the external management of psoriasis: A
systematic review with meta-analysis of RCTs 140
6.2.1 Introduction 140
6.2.2 Method 141
6.2.3 Results 143
6.2.3.1 Description of studies 152
6.2.3.2 Methodological assessment 155
6.2.3.3 Meta-analysis 155
6.2.3.4 AEs 164
6.2.3.5 Principal herbs used in the studies 164

6.2.4 Discussion 165
6.2.5 Summary 168
6.3 Results for systematic review 4: External herbal medicines combined with pharmacotherapy for
psoriasis: A systematic review with meta-analysis of RCTs 168
6.3.1 Introduction 168
6.3.2 Method 168
6.3.3 Results 171
6.3.3.1 Description of studies 171
6.3.3.2 Methodological assessment 178
6.3.3.3 Meta-analysis 178
6.3.3.4 AEs 180
6.3.5 Discussion 181
6.3.6 Summary 182
6.4 Conclusions regarding the external HM RCTs for psoriasis 182
Chapter 7: Investigation of the in vitro and in vivo actions of the main herbs 183
7.1 Introduction to Part 2 183
7.2 Method for in vivo & in vitro studies 183
7.3 Results for in vivo & in vitro studies of the anti-psoriatic actions of the main herbs 184
7.4 Anti-psoriatic actions of the main herbs identified in SR1: medicinal herbs used internally for
psoriasis (7.4.1-7.4.3) 185
7.4.1 Experimental studies of Oldenlandia diffusa (bai hua she she cao) 186
7.4.2 Experimental studies on Rehmannia glutinosa (Di huang) 193
7.4.3 Experimental studies on Salvia miltiorrhiza (Dan shen) 197
Anti-psoriatic actions of the main herbs identified in SR2: single herbs used topically for psoriasis
(7.4.4-7.4.7) 202
7.4.4 Experimental studies on Aloe vera (Lu hui) 202

7.4.5 Experimental studies on Indigo naturalis (Qing dai) 202
7.4.6 Experimental studies on Camptotheca acuminata (Xi shu) 203
7.4.7 Experimental studies on Mahonia aquifolium (Gong lao mu) 204
Anti-psoriatic actions of the main herbs identified in SR3: external herbal formulae for psoriasis
(7.4.8-7.4.9) 205
7.4.8 Experimental studies on Sophora flavescens (Ku shen) 205
7.4.9 Experimental studies on Lithospermum erythrorhizon (Zi cao) 210
Anti-psoriatic actions of the main herbs identified in SR4: external herbs combined with APP for
psoriasis (7.4.10-7.4.12) 216
7.4.10 Experimental studies on Cnidium monnieri 216
7.4.11 Experimental studies on Dictamnus dasycarpus 216
7.4.12 Experimental studies on borneol 217
7.5 Summary 217
7.5.1 Inflammation 218
7.5.2 Proliferation 218
7.5.3 Angiogenesis 219
7.5.4 Wound healing & tissue repair 219
7.5.5 Pruritus 219
Chapter 8: Large-scale biological target and pathway analysis for the main herbs, compounds and
APPs 220
8.1 Introduction 220
8.2 Method 223
8.2.1 General approach 223
8.2.2 Databases and resources 223
8.2.2.1 Encyclopaedia of TCM 224
8.2.2.2 Herbal Ingredients’ Targets database (HIT) 224
8.2.2.3 DrugBank database 225
8.2.2.4 PANTHER database 227
8.2.3 Procedures for in silico analysis 229
8.3 Results 231
8.3.1 Constituents of the promising herbs 231
8.3.2 Biological targets for the compounds in each herbs identified using HIT 236
8.3.2.1 Compounds and targets for Bai hua she she cao (Oldenlandia diffusa) 236
8.3.2.2 Compounds and targets for Di huang (Rehmannia glutinosa) 236
8.3.2.3 Compounds and targets for Dan shen (Salvia miltiorrhiza) 237
8.3.2.4 Compounds and targets for Lu hui (Aloe vera) 238
8.3.2.5 Compounds and targets for Qing dai (Indigo naturalis) 238
8.3.2.6 Compounds and targets for Xi shu (Camptotheca acuminata) 239
8.3.2.7 Compounds and targets for Gong lao mu (Mahonia aquifolium) 239
8.3.2.8 Compounds and targets for Ku shen (Sophora flavescens) 240
8.3.2.9 Compounds and targets for Zi cao (Lithospermum erythrorhizon) 240
8.3.2.10 Compounds and targets for She chuang zi (Cnidium monnieri) 241
8.3.2.11 Compounds and targets for Bai xian pi (Dictamnus dasycarpus) 241
8.3.2.12 Compounds and targets for Bing pian (Dryobalanops aromatica) 241
8.3.3 Identification of APP drug targets using DrugBank 241
8.3.3.1. Targets that the herbs shared with the APPs 242
8.3.3.2 Comparison of target groupings, herbs and APPs 245
8.3.3.3 Comparison of herbs, species and APPs 246
8.3.3.4 APPs that share targets with the herbs 250
8.3.4 Analysis of the pathways associated with biological targets of herbs using PANTHER 253
8.3.4.1 Results of PANTHER analyses 254
8.3.4.2 Main pathways identified for the four herbs 258
8.3.4.3 Main pathways identified for the two APPs 262
8.4 Summary and discussion of results 262
8.4.1 Targets of the herbs 262
8.4.2 Targets of the herbs and APPS 264
8.4.3 Main pathways and proteins 265
8.4.4 Comparison with results of other studies of targets in psoriasis using in silico methods 272
Chapter 9: General discussion and future directions 275
9.1 Summary of the project 275
9.1.1 The approach to the analysis of clinical and experimental studies 275
9.1.2 The selection of herbs for further analysis 276
9.2 The in silico approach to the analyses of herbal medicines in psoriasis 278
9.2.1 Identifying the targets of the herbs 279
9.2.2 Identifying targets of relevance to psoriasis 280
9.2.3 Identifying the pathways 282
9.3 Research questions and main results 283
9.4 Innovative aspects of the project 289
9.4.1 The use of results of SRs to select herbs for further investigation 289
9.4.2 Target-directed large-scale analyses using multiple databases 290
9.5 Implications for further experimental and clinical research in psoriasis 291
9.6 Implications for herbal research and natural products drug discovery 292
9.7 Future research directions 294
References 296

Appendix 1 Biological targets list for Bai hua she she cao A-1
Appendix 2 Biological target list for Di huang A-5
Appendix 3 Biological target list for Dan shen A-15
Appendix 4 Biological target list for Lu hui A-31
Appendix 5 Biological target list for Qing dai A-37
Appendix 6 Biological target list for Xi shu A-45
Appendix 7 Biological target list for Gong lao mu A-53
Appendix 8 Biological target list for Ku shen A-75
Appendix 9 Biological target list for Zi cao A-80
Appendix 10 Biological target list for She chuang zi A-89
Appendix 11 Biological target list for Bai xian pi A-91
Appendix 12 Biological target list for Bing pian A-93
Appendix 13 The list of APP drug targets (from DrugBank) A-94
Appendix 14 List of Molecular Functions identified in PANTHER A-104
Appendix 15 List of Molecular Functions identified in PANTHER A-107
Appendix 16 List of Protein Classes identified in PANTHER A-111
Appendix 17 List of Cellular Components identified in PANTHER A-116
Appendix 18 List of pathways identified in PANTHER A-118
Appendix 19 List of protein targets in the top 5 pathways identified in PANTHER A-127
Appendix 20 Target name in chapter 7 and the corresponding full name in chapter 8 A-144

……………………………………………………………………………………………………………………………………………………………………………………………………………………

 

Medifit  Courses Demo Certificate 

48 hours delivery

| International acceptance | Medical based | Job oriented | Lifetime validity | Most economical |

 

555 INR Demo Certificate – 2 months duration

Demo Certificate – 6 months duration

48 hours delivery after fees payment

48 hours delivery after fees payment

 

Medifit 48 hours Delivery

  Get your Certificates delivered by online mode in 48 hours after Fees payment. We try to deliver certificates in 24 hours, but the committed delivery hours are 48. Its,

Pay Today &
get Tomorrow

procedure, only by Medifit.

LIFETIME VALIDITY

Medifit issues Lifetime validity certificates for all Online Courses provided. No need to renew the certificates every 2 or 3 years. All Courses Certificates of Medifit are having Lifetime Validity. No need to renew these certificates every 2 or 3 years.

 

What makes the certificates of Medifit to get it recognized Internationally?

Vast number of students applying for Job in international market of Fitness through Medifits Online Courses Certificates. And most importantly, the Medical standards maintained, helps to acquire jobs internationally. This gives very strong International acceptance to Certificates of Medifit Courses.

 

ABOUT MEDIFIT ACADEMY CERTIFICATION COURSE:

Medifit Education Online Academy is an innovative, digital and engaging education platform that delivers fast track accredited courses and skills development courses instantly online, with no time limits, enabling individuals to study anywhere and anytime. We are proud to offer international standard courses that have helped our students build their careers across the globe.

HOW DO MEDIFIT ONLINE CERTIFICATE COURSES HELP?

Short term Professional Courses International Standards courses Opens Global opportunities Career defining Courses Skill Development Programmes Knowledge in short span Learn at your own pace Certification of Completion Immediate Earning Opportunities Positive Social Impact Optimistic Psychological Benefits Improved Standard of Living Study from anywhere & anytime Very Economical Fees