215. Vitamins And Cancer

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215. Vitamins And Cancer

 

 

CATEGORY: Diet Nutrition Supplementation – 500 Courses

COURSE NUMBER: 215

FEES: 555/- INR only

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BOOKS/ MANUALS: Pages

Syllabus

Preface………………………………………… v
Introduction and future Perspectives. . . . . . . . . . . . . . . . . . . vii
BASIC EXPERIMENTAL APPROACHES
Studies on the Mechanism of the Antiproliferative Action of
Retinoids Using Retinoid-Resistant Melanoma Cell
Mutants…………………………………….. 3
Reuben Lotan
Retinoids, Polyamines, and Teratocarcinoma Differentiation. . . . 19
Joel Schindler and Michael Kelly
Biochemical Mechanism of Inhibition of Phorbol Ester-Induced
Mouse Epidermal Ornithine Decarboxylase by Retinoic
Acid……………………………………….. 35
Ajit K. Verma
The Effects of Antioxidants on the Induction of Malignant
Transformation In Vitro. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
Ann R. Kennedy
Free Radicals, Dietary AntiOxidants, and Mechanisms in Cancer
Prevention; In Vitro Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Carmia Borek
Ascorbate Effects on Endomembrane Electron Transport and
Membrane Aux. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
D. James Morre, Iris Sun, and F. L. Crane
Modification of Tumor Cell Response In Vitro by Vitamin E. . . . 93
Kedar N. Prasad, Bhola N. Rama, and Richard M.
Detsch
CHEMOPREVENTION (PRECLINICAL)
Nutrients and Other Risk Factors Associated With Cancer. . . . .. 113
Paul M. Newbeme, Thomas F. Schrager, and Michael W.
Conner

Supplemental Carotenoids Prevent Skin Cancer by

Benzo(a)Pyrene, Breast Cancer by Puva, and Gastric Can-
cer by MNNG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 139

L. Santamaria, A. Bianchi, A. Amaboldi, L. Andreoni,
G. Santagati, C. Ravetto, L. Bianchi, R. Pizzala, and
P.Bermond
Retinoids as Chemopreventive Agents: Alone and in
Combination. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 161
R. C. Moon, D. L. McCormick, and R. G. Mehta
Dietary Cholesterol and Colon Tumorigenesis Induced by
1,2-Dimethylhydrazine or N-Methyl-N-Nitrosourea in Rats. 181
Selwyn A. Broitman, Herbert Kupchik, and Leonard S.
Gottlieb
Effects of Vitamin E on the Immune System ……………. , 199
Mary P. Carpenter

Mechanism and Prevention of Anticancer Agent-Induced Can-
cer; Interactions of Vitamin E and Daunorubicin ……… , 213

Yeu-Ming Wang

CHEMOPREVENTION (HUMAN)
Methodological Issues

A New HPLC Method for the Simultaneous Analysis of Plasma
Retinol, Tocopherols, and Carotenoids and Its Application
in Cancer Epidemology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 231
Chung S. Yang, Kenneth W. Miller, and Mao-Jung Lee
Clinical Toxicology Pharmacokinetics of 13-cis-Retinoic Acid

Administered Chronically at Low Doses Expected for Can-
cer Chemoprevention Trials. . . . . . . . . . . . . . . . . . . . . . . . . .. 245

David S. Alberts, libby Edwards, Yei-Mel Peng, Ruth
Serokman, Thomas P. Davis, and Frank L.
Meyskens, Jr.
Changing the Public’s Health Behaviors by Diet and
Chemopreventive Interventions . . . . . . . . . . . . . . . . . . . . . . .. 257
Curtis Mettlin
Design and Compliance Considerations of Dietary Intervention
Trials ……………………………………….. 267
Thomas E. Moon, Steven Rodney, Yel-Mei Peng, David
S. Alberts, and Frank L. Meyskens, Jr.

Contents xv
Methodologic Issues in Clinical Trials. . . . . . . . . . . . . . . . . . . . . . .. 283
Charles H. Hennekens and Sherry Mayrent
Prevention Trials

Diet and Cancer Prevention Update on National Cancer Insti-
tute Initiative . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 293

Peter Greenwald
The Chemoprevention Program of the National Cancer
Institute. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 301
William D. DeWys, Winfred F. Malone, Mary Ann
Sestili, Gary J. Kelloff, and Charles W. Boone
Nutrition Intervention Studies of the Esophageal Cancer in
Linxian, China. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 311
Jun-Vao Li
Chemoprevention Studies in Familial Polyposis. . . . . . . . . . . . . .. 329
L. S. Freedman, S. Groshen, H. H. Miller, and J. J.
DeCosse
Chemoprevention of Lung Cancer With Retinol/Beta-Carotene. 341
G. E. Goodman, G. S. Omenn, P. Feigl, G. D.
Kleinman, B. Lund, D. D. Thomas, N. M.
Henderson, and R. Prentice
Highlights of Methodological Approaches: A Case-Control
Study of Diet and Breast Cancer. . . . . . . . . . . . . . . . . . . . . .. 351
M. Moseson, R. E. Shore, and C. M. Lazaro

TREATMENT

Ascorbic Acid and Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 365
A. Hanck
The Role of Vitamin C in Tumor Therapy (Human). . . . . . . . . .. 399
Fukumi Morishige, Takahide Nakamura, Naoko
Nakamura, and Noritsugu Morishige
Vitamin B6 Status and Administration During Radiation
Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 429
H. A. Ladner and R. M. Salkeld
Retinoids and Vitamin E: Modulators of Immune Functions and
Cancer Resistance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 439
Ronald Ross Watson

Clinical Trials and In Vitro Studies of 13-cis-Retinoic Acid in the
Myelodysplastic Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . .. 453
Emmanuel C. Besa, Martin Hyzinski, Peter Nowell, and
Janet Abrahm
Experience With Retinoids as Prevention and Treatment for
Human Cancers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 471
Frank L. Meyskens, Jr.
Index ………………………………………….. 479

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