140. Pathology For Pharmacists

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140. Pathology For Pharmacists

140. Pathology For Pharmacists

 

 

CATEGORY: Medical & Medicine – 500 Courses

COURSE NUMBER: 140

FEES: 555/- INR only

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BOOKS/ MANUALS: Pages

Syllabus

Dedication and acknowledgements
with a note on drug nomenclature x
Preface to the third edition xiii
Extract from preface to the first edition xv
About the authors xvii
Recommended reference sources xviii
Abbreviations xx
Plate section between pages 854 and 855
PART 1 Basic strategy and introduction to pathology 1
1 Therapeutics: general strategy 3
Terminology of disease 4
Case history 8
Drug disposition 13
Drug selection 15
References and further reading 22
2 Major pathological processes in disease 23
Introduction 23
Immunology 25
Inflammation 46
Ischaemia 58
References and further reading 63
PART 2 Body systems and their principal diseases 65
3 Gastrointestinal and liver diseases 67
Gastrointestinal anatomy and physiology 68
Investigation 78
Disorders of the upper gastrointestinal tract 82
Oesophageal disorders 82

Helicobacter infection and gastroduodenal disease 88
Dyspepsia 91
Peptic ulcer disease 96
Nausea and vomiting 107
Problems of the small and large intestine 111
Malabsorption 111
Inflammatory bowel disease 114
Other colonic and rectal disorders 124
Stomatherapy 133
Liver diseases 138
Clinical physiology of the liver 138
Clinical features of hepatic disease 143
Gallstones (cholelithiasis) 150
Liver failure 152
Viral and other infective hepatitis 156
Drugs and the liver 159
References and further reading 162
4 Cardiovascular system 165
Physiological principles of the cardiovascular system 166
Clinical features of cardiovascular disease 182
Heart failure 186
Hypertension 208
Ischaemic heart disease 235
Atherosclerosis and vascular obstructive disease 235
Angina pectoris 249
Myocardial infarction 258
Acute coronary syndrome 266
Summary of cardiovascular aetiologies 269
References and further reading 270
5 Respiratory diseases 271
Anatomy and clinical physiology of the respiratory system 272
Clinical aspects of respiratory disease 281
Obstructive pulmonary disease 292
Asthma 292
Other allergic lung diseases 325
Chronic obstructive pulmonary disease 326
Restrictive lung disease 342
Diseases of the pulmonary circulation 342
Respiratory failure 346
Inhalation therapy 348
Oxygen therapy 360
References and further reading 364

6 Central nervous system 365
Physiological principles 366
Psychiatric disorder 371
Clinical aspects of psychiatric disorder 371
Anxiety 374
Affective disorder: depression 385
Mania and manic-depressive disorder 403
Schizophrenia 408
Neurological disorder 426
Parkinson’s disease and the extrapyramidal syndromes 426
Epilepsy 439
References and further reading 454
7 Pain and its treatment 455
Introduction 456
Pathophysiology of pain 459
Principles of analgesic use 463
Analgesic drugs and techniques 468
Opioid analgesics 468
Less potent analgesics 478
Analgesic adjuvants 479
Other methods of pain control 482
Local anaesthetics 482
Topical agents 485
Physical methods 485
Techniques recruiting endogenous inhibitory mechanisms 485
Chemical nerve blocks 487
Neurosurgical approaches 488
Psychotherapy and hypnosis 489
Syringe drivers and patient-controlled analgesia 489
Some common pain situations 491
Headache, migraine and facial pain 491
Post-herpetic neuralgia 505
Some special pain situations 506
References and further reading 511
8 Infections and antimicrobial therapy 513
Introduction 514
Classification of microorganisms 514
Classification and properties of antimicrobials 517
Penicillins 518
Cephalosporins 521
Aminoglycosides 523
Other antimicrobial agents 525
Antifungal agents 532

Antiviral agents 534
Therapeutic decisions in antimicrobial therapy 536
Some important infections 548
References and further reading 578
9 Endocrine system 581
Diabetes mellitus 582
Physiological principles of glucose and insulin metabolism 582
Epidemiology and classification 587
Aetiology and pathogenesis 589
Natural history 591
Clinical features 593
Complications 593
Management 604
Monitoring 628
Thyroid disease 630
Physiological principles 630
Hypothyroidism 633
Hyperthyroidism 637
References and further reading 643
10 Neoplastic disease 645
Classification and epidemiology of cancer 646
Aetiology 649
Pathobiology 653
Cytokinetics 657
Clinical features 668
Investigation and diagnosis 671
Management: aims and strategy 673
Cytotoxic chemotherapy 677
Endocrine therapy 693
Other pharmacotherapy 695
Rational design of antineoplastic regimens 701
References and further reading 704
11 Haematology 705
Red blood cell production and function 705
Anaemia 710
Neutropenia and agranulocytosis 725
Haemostasis, fibrinolysis and anticoagulation 726
References and further reading 741
12 Rheumatology: musculoskeletal and connective tissue diseases 743
Introduction 744
Anatomy and physiological principles of the musculoskeletal system 744

The immune system and rheumatic diseases 748
Examination, investigation and assessment 750
Principal arthritic diseases 754
Osteoarthritis 754
Rheumatoid arthritis 761
Seronegative spondarthritides 789
Ankylosing spondylitis 789
Crystal deposition arthropathies 791
Common features and pathology 791
Gout 792
Pyrophosphate arthropathy 798
Autoimmune connective tissue disorders 798
Systemic lupus erythematosus 798
Sjögren’s syndrome (keratoconjunctivitis sicca) 801
Systemic sclerosis and scleroderma 803
Raynaud’s syndrome 804
Vasculitides 805
Other multisystem diseases 807
Other rheumatic disorders 809
Reactive arthritis 809
Soft tissue rheumatism 809
References and further reading 813
13 Skin diseases 815
Skin anatomy and physiology 816
Clinical features of skin diseases 819
General management of skin diseases 827
Psoriasis 838
Eczema and dermatitis 849
Acne 856
Rosacea 863
Urticaria 864
Drug-induced skin disease 866
The skin as a route for systemic drug delivery 867
References and further reading 867
14 Renal system 869
Physiological principles of the renal system 869
Clinical features and investigation of renal disease 882
Renal failure 897
Renal replacement therapy 916
Important renal diseases 929
References and further reading 942
Index 943

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