107. Proteomics & Protein

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107. Proteomics & Protein

 

 

CATEGORY: Diet Nutrition Supplementation – 500 Courses

COURSE NUMBER: 107

FEES: 555/- INR only

CERTIFICATE VALIDITY: Lifetime

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BOOKS/ MANUALS: Pages

Syllabus

Preface v
Gabriel Waksman
1. Introduction 01
Gabriel Waksman and Claire Sansom

2. Yeast Two-Hybrid Protein–Protein Interaction Networks 19
Daniel Auerbach and Igor Stagljar

3. The Use of Mass Spectrometry in Studying Protein–Protein Interaction 33
Yi Wang, Parvin Yazdi, and Jun Qin

4. Molecular Recognition in the Immune System 49
Eric J. Sundberg and Roy A. Mariuzza

5. Computational Methods for Predicting Protein–Protein Interactions 89
A. Walker-Taylor and D.T. Jones

6. Protein–Protein Docking Methods 115
Garland R. Marshall and Ilya A. Vakser

7. Thermochemistry of Binary and Ternary Protein Interactions Measured
by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and
Anti-gp120 147
Michael L. Doyle and Preston Hensley

8. Protein–Protein Recognition in Phosphotyrosine-Mediated Intracellular
Signaling 165
John E. Ladbury

9. Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other
Functionally Related Protein Domains 185
Marius Sudol and Mark T. Bedford

10. The Structure and Molecular Interactions of the Bromodomain 203
Kelley S. Yan and Ming-Ming Zhou

11. SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based
Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src) 219
T.K. Sawyer, R.S. Bohacek, W.C. Shakespeare, C.A. Metcalf, III,
Y. Wang, R. Sundaramoorthi, T. Keenan, S. Narula, and D.C. Dalgarno

12. Disrupting Protein–Protein Interaction: Therapeutic Tools Against Brain
Damage 255
Michelle Aarts and Michael Tymianski

13. A Thermodynamic Guide to Affinity Optimization of Drug Candidates 291
Ernesto Freire
Index 309

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